Effects of lorglumide and atropine on MgSO4-induced gallbladder emptying in conscious dogs

Ágnes Sterczer, G. Szénási, K. Vörös, A. Pap

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The aim of the study was to examine the possible involvement of cholecystokinin (by lorglumide) and cholinergic mechanisms (by atropine) in magnesium sulphate (MgSO4)-induced gallbladder contraction of conscious dogs. The gallbladder (GB) volume was determined by ultrasonography. The optimal dose of 80 mg kg-1 of MgSO4 was determined from a MgSO4 dose-response curve using doses of 10, 20, 40, 80, 120 mg kg-1. The largest dose of MgSO4 was less effective than the optimal dose. Peak gallbladder contraction (32 per cent) was achieved at 30 minutes. Atropine (50 μg kg-1 s.c.) or lorglumide (1 mg kg-1 p.o.) fully prevented GB contraction. In conclusion, supraoptimal doses of MgSO4 have a diminishing effect. The sustained contraction of the gallbladder in response to the optimal dose of MgSO4 can be explained by an additive effect of the cholecystokinin release and a cholinergic trigger mechanism. Ultrasonography and MgSO4 stimulation proved to be a valuable technique for examination of gallbladder motility. (C) 2000 Harcourt Publishers Ltd.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalResearch in Veterinary Science
Volume69
Issue number2
DOIs
Publication statusPublished - Oct 2000

Fingerprint

Gallbladder Emptying
gall bladder
atropine
Gallbladder
Atropine
Dogs
dogs
dosage
cholecystokinin
Cholecystokinin
cholinergic agents
ultrasonography
Cholinergic Agents
Ultrasonography
magnesium sulfate
Magnesium Sulfate
additive effect
dose response
lorglumide

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Effects of lorglumide and atropine on MgSO4-induced gallbladder emptying in conscious dogs. / Sterczer, Ágnes; Szénási, G.; Vörös, K.; Pap, A.

In: Research in Veterinary Science, Vol. 69, No. 2, 10.2000, p. 129-133.

Research output: Contribution to journalArticle

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