Effects of levosimendan on the energy balance: Preclinical and clinical evidence

Markku S. Nieminen, Piero Pollesello, Gusztáv Vajda, Zoltán Papp

Research output: Contribution to journalReview article

23 Citations (Scopus)


Levosimendan is a novel inodilator agent, which enhances myocardial performance without substantial changes in oxygen consumption. The combination of positive inotropic and vasodilator effects of levosimendan relates to its Ca-sensitizing and K channel opening effects. Levosimendan is one of the best documented pharmacological agents used in the management of acute heart failure syndromes. Interest in levosimendan has recently been renewed owing to its potential in supporting cardiac function in patients with ischemic heart disease and cardiogenic or septic shock. It has been also demonstrated that levosimendan can be used as a bridge therapy for the perioperative phase of cardiac surgery. The ability of levosimendan to improve myocardial function without substantially increasing oxygen consumption may appear paradoxical but is indeed possible via improved efficacy, not only with regard to the effects on the contractile apparatus of the cardiomyocytes but also when its composite hemodynamic effects are considered. The energy balance equation, therefore, should take into account the effect of levosimendan on all energy-consuming and energy-producing paths. Moreover, levosimendan-evoked KATP channel opening may possess favorable effects on mitochondrial adenosine triphosphate synthesis conferring cardioprotection during ischemic insults.

Original languageEnglish
Pages (from-to)302-310
Number of pages9
JournalJournal of cardiovascular pharmacology
Issue number4
Publication statusPublished - Apr 1 2009


  • ATP-sensitive potassiumchannels
  • Ca sensitization
  • Cardioprotection
  • Cardiovascular energetics
  • Levosimendan
  • Vasodilation

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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