Effects of lead(II) nitrate and a dithiocarbamate fungicide on the rat lung

Zoltán Adamis, Erzsébet Tátrai, Koichi Honma, György Ungváry

Research output: Contribution to journalArticle

1 Citation (Scopus)


The pulmonary toxicity of two potential environmental pollutants was studied in rats 1, 7 and 30 days after a single intratracheal instillation of lead nitrate and Dithane M-45 (mancoceb), either individually or in various combinations. The cell count, protein, phospholipids and lactate dehydrogenase level were determined in the bronchoalveolar lavage fluid, as were the protein, phospholipids and acid phosphatase contents in the lung tissue. Lead nitrate and Dithane M-45 induced acute inflammation reactions with different features. The effects of mixtures of lead nitrate and Dithane M-45 were found to be different from those of the individual components.

Original languageEnglish
Pages (from-to)347-350
Number of pages4
JournalJournal of Applied Toxicology
Issue number5
Publication statusPublished - Sep 1 1999


  • Acid phosphatase
  • Bronchoalveolar lavage
  • Dithiocarbamate fungicide
  • Lactate dehydrogenase
  • Lead nitrate
  • Phospholipid
  • Protein

ASJC Scopus subject areas

  • Toxicology

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