Effects of joining peptide (1-18) and histamine on dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) production of human adrenocortical cells in vitro

Evelyn Orsó, K. Sz Szalay, D. Szabó, E. Stark, T. Fehér, F. Perner, M. Hidvégi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Joining peptide 1-18 (JP 1-18), added alone in concentrations of 10-13-10-7 M to collagenase-dispersed human adrenocortical cells, did not affect the basal production of corticosterone, cortisol, aldosterone, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS). JP 1-18 potentiated the ACTH-stimulated production of steroids. When administered in combination with histamine (10-8-10-3 M), JP 1-18 (10-8 or 10-10 M), enhanced the synthesis of DHEA and DHEAS. JP 1-18, together with histamine, may play a role in the regulation of DHEA and DHEAS production.

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume58
Issue number2
DOIs
Publication statusPublished - May 1996

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Dehydroepiandrosterone Sulfate
Dehydroepiandrosterone
Joining
Histamine
Peptides
Collagenases
Corticosterone
Aldosterone
Steroids
Adrenocorticotropic Hormone
Hydrocortisone
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Effects of joining peptide (1-18) and histamine on dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) production of human adrenocortical cells in vitro. / Orsó, Evelyn; Szalay, K. Sz; Szabó, D.; Stark, E.; Fehér, T.; Perner, F.; Hidvégi, M.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 58, No. 2, 05.1996, p. 207-210.

Research output: Contribution to journalArticle

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