Effects of joining peptide (1-18) and histamine on dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) production of human adrenocortical cells in vitro

Evelyn Orsó, K. Sz Szalay, D. Szabó, E. Stark, T. Fehér, F. Perner, M. Hidvégi

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Abstract

Joining peptide 1-18 (JP 1-18), added alone in concentrations of 10-13-10-7 M to collagenase-dispersed human adrenocortical cells, did not affect the basal production of corticosterone, cortisol, aldosterone, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS). JP 1-18 potentiated the ACTH-stimulated production of steroids. When administered in combination with histamine (10-8-10-3 M), JP 1-18 (10-8 or 10-10 M), enhanced the synthesis of DHEA and DHEAS. JP 1-18, together with histamine, may play a role in the regulation of DHEA and DHEAS production.

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume58
Issue number2
DOIs
Publication statusPublished - May 1996

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

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