Effects of ischemia on opioid receptors in newborn pig lumbar spinal cord.

K. Gulya, P. Tekulics, P. Kása

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The characteristics of opioid receptors were studied by the binding of (3H)naloxone in ischemic lumbar spinal cord segments of newborn pigs. Ischemia was elicited by ligating the aorta for 30 min. The number of millimicron opioid receptors decreased, from 117 +/- 18 to 89 +/- 11 fmol/mg protein, while the Kd value was not significantly altered. It is concluded that even a relatively brief interruption of the oxygen supply may cause severe damage in the lumbar spinal cord of the newborn pig, affecting the opioid neurotransmission. The animal model employed here might be suitable for studying the effects of hypoxia in newborns and children during chest operations involving the descending aorta.

Original languageEnglish
Pages (from-to)229-235
Number of pages7
JournalActa Biologica Hungarica
Volume40
Issue number3
Publication statusPublished - 1989

Fingerprint

narcotics
Opioid Receptors
ischemia
spinal cord
pig
Spinal Cord
neonates
Swine
Ischemia
aorta
Oxygen supply
receptors
swine
hypoxia
Naloxone
Opioid Analgesics
naloxone
Animals
chest
oxygen

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Effects of ischemia on opioid receptors in newborn pig lumbar spinal cord. / Gulya, K.; Tekulics, P.; Kása, P.

In: Acta Biologica Hungarica, Vol. 40, No. 3, 1989, p. 229-235.

Research output: Contribution to journalArticle

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