Effects of intraventricularly injected isoosmolar glycerol on brain water and electrolytes in the rat

T. Doczi, P. Szerdahelyi, F. Joo, M. Bodosi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The infusion of isoosmolar glycerol (0.35 mol/dm-3) into the ventricles of laboratory rats for 120 minutes led to an increase in the serum osmolality by 11 mosm/kg and to hypernatremia. The brain water content of the cerebral hemispheres decreased by 0.9% (P < 0.05). A corresponding intraventricular infusion of saline or d-glucose did not cause significant changes in these parameters. These findings support the view that glycerol, even in a dose incapable of creating a major osmotic gradient between plasma and brain, could have a beneficial effect in the control of intracranial volume-pressure perturbations. It is hypothesized that, besides acting as an osmotic dehydrating agent in certain concentrations, glycerol influences the central neuroendocrine system responsible for brain ion and volume homeostasis. By its presumed reduction of central and peripheral vasopressin release through lowering the cerebrospinal fluid sodium concentration, it may help in decreasing the brain water content.

Original languageEnglish
Pages (from-to)182-185
Number of pages4
JournalNeurosurgery
Volume21
Issue number2
DOIs
Publication statusPublished - Jan 1 1987

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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