Effects of intracerebroventricular injection of Delta Sleep-Inducing Peptide (DSIP) and an analogue on sleep and brain temperature in rats at night

F. Obál, A. Török, P. Alföldi, G. Sáry, M. Hajós, B. Penke

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The effects of ICV injections of DSIP and ω-amino-caprilyl-DSIP (C-DSIP) on the sleep-wake activity and brain temperature (Tbr were studied in rats. The substances (7 nmol/kg) were injected at dark onset, and the sleep-wake activity and Tbr were recorded for 24 hr (dark and light periods, 12 hr each). Relative to the control recordings obtained after artificial CSF injection, the duration of sleep did not increase after either DSIP or C-DSIP. The only significant reaction was an increase of W 6 to 9 hr after the injection of either peptide. The course of Tbr after DSIP and C-DSIP was also indentical to that recorded after the injection of artificial CSF. It seems that DSIP administered in a single ICV injection at dark onset does not promote sleep. The increase in W might be attributed to an indirect effect of DSIP or to a degradation product of the peptide.

Original languageEnglish
Pages (from-to)953-957
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume23
Issue number6
DOIs
Publication statusPublished - 1985

Fingerprint

Delta Sleep-Inducing Peptide
Rats
Brain
Sleep
Injections
Temperature
Peptides
Light
Degradation

Keywords

  • Brain temperature
  • DSIP
  • Sleep
  • Sleep-promoting substances

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Effects of intracerebroventricular injection of Delta Sleep-Inducing Peptide (DSIP) and an analogue on sleep and brain temperature in rats at night. / Obál, F.; Török, A.; Alföldi, P.; Sáry, G.; Hajós, M.; Penke, B.

In: Pharmacology, Biochemistry and Behavior, Vol. 23, No. 6, 1985, p. 953-957.

Research output: Contribution to journalArticle

@article{59e033efba444567a4c26cf6849b6fe0,
title = "Effects of intracerebroventricular injection of Delta Sleep-Inducing Peptide (DSIP) and an analogue on sleep and brain temperature in rats at night",
abstract = "The effects of ICV injections of DSIP and ω-amino-caprilyl-DSIP (C-DSIP) on the sleep-wake activity and brain temperature (Tbr were studied in rats. The substances (7 nmol/kg) were injected at dark onset, and the sleep-wake activity and Tbr were recorded for 24 hr (dark and light periods, 12 hr each). Relative to the control recordings obtained after artificial CSF injection, the duration of sleep did not increase after either DSIP or C-DSIP. The only significant reaction was an increase of W 6 to 9 hr after the injection of either peptide. The course of Tbr after DSIP and C-DSIP was also indentical to that recorded after the injection of artificial CSF. It seems that DSIP administered in a single ICV injection at dark onset does not promote sleep. The increase in W might be attributed to an indirect effect of DSIP or to a degradation product of the peptide.",
keywords = "Brain temperature, DSIP, Sleep, Sleep-promoting substances",
author = "F. Ob{\'a}l and A. T{\"o}r{\"o}k and P. Alf{\"o}ldi and G. S{\'a}ry and M. Haj{\'o}s and B. Penke",
year = "1985",
doi = "10.1016/0091-3057(85)90099-1",
language = "English",
volume = "23",
pages = "953--957",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Effects of intracerebroventricular injection of Delta Sleep-Inducing Peptide (DSIP) and an analogue on sleep and brain temperature in rats at night

AU - Obál, F.

AU - Török, A.

AU - Alföldi, P.

AU - Sáry, G.

AU - Hajós, M.

AU - Penke, B.

PY - 1985

Y1 - 1985

N2 - The effects of ICV injections of DSIP and ω-amino-caprilyl-DSIP (C-DSIP) on the sleep-wake activity and brain temperature (Tbr were studied in rats. The substances (7 nmol/kg) were injected at dark onset, and the sleep-wake activity and Tbr were recorded for 24 hr (dark and light periods, 12 hr each). Relative to the control recordings obtained after artificial CSF injection, the duration of sleep did not increase after either DSIP or C-DSIP. The only significant reaction was an increase of W 6 to 9 hr after the injection of either peptide. The course of Tbr after DSIP and C-DSIP was also indentical to that recorded after the injection of artificial CSF. It seems that DSIP administered in a single ICV injection at dark onset does not promote sleep. The increase in W might be attributed to an indirect effect of DSIP or to a degradation product of the peptide.

AB - The effects of ICV injections of DSIP and ω-amino-caprilyl-DSIP (C-DSIP) on the sleep-wake activity and brain temperature (Tbr were studied in rats. The substances (7 nmol/kg) were injected at dark onset, and the sleep-wake activity and Tbr were recorded for 24 hr (dark and light periods, 12 hr each). Relative to the control recordings obtained after artificial CSF injection, the duration of sleep did not increase after either DSIP or C-DSIP. The only significant reaction was an increase of W 6 to 9 hr after the injection of either peptide. The course of Tbr after DSIP and C-DSIP was also indentical to that recorded after the injection of artificial CSF. It seems that DSIP administered in a single ICV injection at dark onset does not promote sleep. The increase in W might be attributed to an indirect effect of DSIP or to a degradation product of the peptide.

KW - Brain temperature

KW - DSIP

KW - Sleep

KW - Sleep-promoting substances

UR - http://www.scopus.com/inward/record.url?scp=0022387723&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022387723&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(85)90099-1

DO - 10.1016/0091-3057(85)90099-1

M3 - Article

C2 - 3841214

AN - SCOPUS:0022387723

VL - 23

SP - 953

EP - 957

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 6

ER -