Effects of intracerebroventricular administration of calcitonin gene-related peptide on passive avoidance behaviour in rats

A. Kovács, G. Telegdy

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The effects of different doses of calcitonin gene-related peptide (CGRP) on passive avoidance behaviour were studied in male rats following its intracerebroventricular (i.c.v) administration. Treatment with doses of 200 ng, 300 ng, 500 ng or 1 μg was performed prior to learning, immediately and 6 h after the learning session and 30 min before the 24 h retention test. CGRP enhanced the avoidance latency in a dose-dependent manner at each time studied, with the exception of 6 h after the learning session. It is concluded that CGRP might be able to lengthen the passive avoidance latency by facilitating learning and memory formation.

Original languageEnglish
Pages (from-to)51-54
Number of pages4
JournalNeuropeptides
Volume23
Issue number1
DOIs
Publication statusPublished - Sep 1992

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ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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