Effects of intraarterial chemotherapy of tumours of the head and neck on the cerebral circulation

L. Pavics, G. Szabo, Z. Toth Bagi, E. Ambrus, L. Almasi, L. Csernay

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A combination of cisplatin and farmorubicin was administered through the external carotid artery system, according to a standard protocol, as preoperative or palliative therapy in 14 oral cancer patients. With the aim of clarifying the subacute side-effects of this chemotherapy on the intracerebral circulation, regional cerebral blood fow (rCBF) single-photon emission computed tomography (SPECT) investigations with [99mTc]hexamethylpropyleneamine oxime were performed before and after the cytostatic treatment. The interval between SPECT studies was 24 (SD ± 12) days. In concordance with the neurological condition, visual assessment of the rCBF-SPECT-reconstructed transversal slices revealed no perfusion abnormalities and no changes on the follow-up. No significant changes were found in the side-activity ratios in 22 regions of each hemisphere (unpaired t-test) in the whole group of patients. In the subgroup of patients treated on the left side at the orbitofrontal and superior occipital region a statistically significant perfusion alteration was found without a clear-cut biological meaning. It was concluded that this highly effective combination of cytostatics administered perfectly through the external carotid artery system causes no serious disturbances in the cerebral circulation in oral cancer cases.

Original languageEnglish
Pages (from-to)148-151
Number of pages4
JournalRegional Cancer Treatment
Issue number3
Publication statusPublished - Jan 1 1991


ASJC Scopus subject areas

  • Oncology
  • Pharmacology

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