Effects of insulin on potassium currents of rat ventricular myocytes in streptozotocin diabetes

J. Magyar, Z. Cseresnyes, Z. Rusznak, I. Sipos, G. Szucs, L. Kovacs

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Membrane currents of ventricular cardiomyocytes isolated from control, diabetic and insulin-treated diabetic Wistar rats have been measured using the whole cell configuration of the patch-clamp technique. Insulin restored the density of the 4-aminopyridine-sensitive early transient component of the calcium-independent outward potassium currents which decreased in diabetes. The inactivation rate of the transients increased in diabetes and was normalised by insulin. The late 4-aminopyridine-insensitive component of the outward currents showed the same diabetes- and insulin-related changes. This current could reflect the activation of the delayed rectifier channels although pharmacological identification of this component could not be achieved.

Original languageEnglish
Pages (from-to)191-201
Number of pages11
JournalGeneral physiology and biophysics
Volume14
Issue number3
Publication statusPublished - Jan 1 1995

Keywords

  • 4-aminopyridine
  • diabetes
  • insulin
  • outward potassium currents

ASJC Scopus subject areas

  • Biophysics
  • Physiology

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