Effects of insulin on potassium currents of rat ventricular myocytes in streptozotocin diabetes

J. Magyar, Z. Cseresnyes, Z. Rusznak, I. Sipos, G. Szücs, L. Kovacs

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Membrane currents of ventricular cardiomyocytes isolated from control, diabetic and insulin-treated diabetic Wistar rats have been measured using the whole cell configuration of the patch-clamp technique. Insulin restored the density of the 4-aminopyridine-sensitive early transient component of the calcium-independent outward potassium currents which decreased in diabetes. The inactivation rate of the transients increased in diabetes and was normalised by insulin. The late 4-aminopyridine-insensitive component of the outward currents showed the same diabetes- and insulin-related changes. This current could reflect the activation of the delayed rectifier channels although pharmacological identification of this component could not be achieved.

Original languageEnglish
Pages (from-to)191-201
Number of pages11
JournalGeneral Physiology and Biophysics
Volume14
Issue number3
Publication statusPublished - 1995

Fingerprint

Experimental Diabetes Mellitus
Muscle Cells
Potassium
Insulin
4-Aminopyridine
Patch-Clamp Techniques
Cardiac Myocytes
Wistar Rats
Pharmacology
Calcium
Membranes

Keywords

  • 4-aminopyridine
  • diabetes
  • insulin
  • outward potassium currents

ASJC Scopus subject areas

  • Biophysics
  • Physiology

Cite this

Effects of insulin on potassium currents of rat ventricular myocytes in streptozotocin diabetes. / Magyar, J.; Cseresnyes, Z.; Rusznak, Z.; Sipos, I.; Szücs, G.; Kovacs, L.

In: General Physiology and Biophysics, Vol. 14, No. 3, 1995, p. 191-201.

Research output: Contribution to journalArticle

Magyar, J. ; Cseresnyes, Z. ; Rusznak, Z. ; Sipos, I. ; Szücs, G. ; Kovacs, L. / Effects of insulin on potassium currents of rat ventricular myocytes in streptozotocin diabetes. In: General Physiology and Biophysics. 1995 ; Vol. 14, No. 3. pp. 191-201.
@article{3f4cef778ab24549860c558cd7886982,
title = "Effects of insulin on potassium currents of rat ventricular myocytes in streptozotocin diabetes",
abstract = "Membrane currents of ventricular cardiomyocytes isolated from control, diabetic and insulin-treated diabetic Wistar rats have been measured using the whole cell configuration of the patch-clamp technique. Insulin restored the density of the 4-aminopyridine-sensitive early transient component of the calcium-independent outward potassium currents which decreased in diabetes. The inactivation rate of the transients increased in diabetes and was normalised by insulin. The late 4-aminopyridine-insensitive component of the outward currents showed the same diabetes- and insulin-related changes. This current could reflect the activation of the delayed rectifier channels although pharmacological identification of this component could not be achieved.",
keywords = "4-aminopyridine, diabetes, insulin, outward potassium currents",
author = "J. Magyar and Z. Cseresnyes and Z. Rusznak and I. Sipos and G. Sz{\"u}cs and L. Kovacs",
year = "1995",
language = "English",
volume = "14",
pages = "191--201",
journal = "General Physiology and Biophysics",
issn = "0231-5882",
publisher = "Slovak Academy of Sciences",
number = "3",

}

TY - JOUR

T1 - Effects of insulin on potassium currents of rat ventricular myocytes in streptozotocin diabetes

AU - Magyar, J.

AU - Cseresnyes, Z.

AU - Rusznak, Z.

AU - Sipos, I.

AU - Szücs, G.

AU - Kovacs, L.

PY - 1995

Y1 - 1995

N2 - Membrane currents of ventricular cardiomyocytes isolated from control, diabetic and insulin-treated diabetic Wistar rats have been measured using the whole cell configuration of the patch-clamp technique. Insulin restored the density of the 4-aminopyridine-sensitive early transient component of the calcium-independent outward potassium currents which decreased in diabetes. The inactivation rate of the transients increased in diabetes and was normalised by insulin. The late 4-aminopyridine-insensitive component of the outward currents showed the same diabetes- and insulin-related changes. This current could reflect the activation of the delayed rectifier channels although pharmacological identification of this component could not be achieved.

AB - Membrane currents of ventricular cardiomyocytes isolated from control, diabetic and insulin-treated diabetic Wistar rats have been measured using the whole cell configuration of the patch-clamp technique. Insulin restored the density of the 4-aminopyridine-sensitive early transient component of the calcium-independent outward potassium currents which decreased in diabetes. The inactivation rate of the transients increased in diabetes and was normalised by insulin. The late 4-aminopyridine-insensitive component of the outward currents showed the same diabetes- and insulin-related changes. This current could reflect the activation of the delayed rectifier channels although pharmacological identification of this component could not be achieved.

KW - 4-aminopyridine

KW - diabetes

KW - insulin

KW - outward potassium currents

UR - http://www.scopus.com/inward/record.url?scp=0028876396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028876396&partnerID=8YFLogxK

M3 - Article

C2 - 8586253

AN - SCOPUS:0028876396

VL - 14

SP - 191

EP - 201

JO - General Physiology and Biophysics

JF - General Physiology and Biophysics

SN - 0231-5882

IS - 3

ER -