Effects of indomethacin, prostaglandins E2 and I2 on the tone of human isolated femoral arteries

P. Hadhazy, L. Nagy, L. Domotor, K. Magyar

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Abstract

Strips of endothelium-denuded femoral arteries from operated patients were set up for isometric recording. Indomethacin (IND, 3 μmol l-1) enhanced basal tension of the arteries from 0.13 ± 0.04 to 0.86 ± 0.12 mN (P 50 for NA was 1.5 ± 0.3 μmol l-1 (n=6) in the absence, and 0.4 ± 0.07 μmol l-1 (n=6) in the presence of IND (P 2 produced dose-related relaxation in IND-treated vessels, its IC50 being 15.0 ± 1.3 nmol l-1. Low concentrations of PGE2 (0.85-8.5 nmol l-1) reduced whereas its higher concentrations (28-85 nmol l-1) increased smooth muscle tone in the presence of IND. These results indicate that human femoral arteries - unlike femoral arteries of some laboratory animals - are highly sensitive to cyclooxygenase inhibition as well as to PGI2 and PGE2.

Original languageEnglish
Pages (from-to)248-251
Number of pages4
JournalEuropean Journal of Clinical Investigation
Volume16
Issue number3
Publication statusPublished - 1986

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Epoprostenol
Femoral Artery
Dinoprostone
Indomethacin
Prostaglandin-Endoperoxide Synthases
Muscle Hypertonia
Muscle
Animals
Laboratory Animals
Inhibitory Concentration 50
Endothelium
Smooth Muscle
Arteries

ASJC Scopus subject areas

  • Medicine(all)

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Effects of indomethacin, prostaglandins E2 and I2 on the tone of human isolated femoral arteries. / Hadhazy, P.; Nagy, L.; Domotor, L.; Magyar, K.

In: European Journal of Clinical Investigation, Vol. 16, No. 3, 1986, p. 248-251.

Research output: Contribution to journalArticle

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