Effects of H1 and H2 receptor antagonists on Tetrahymena

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Abstract

In Tetrahymena pyriformis the phagocytotic rate increases in response to histamine, but neither the H1 antagonist phenindamine nor the H2 antagonist metiamide stimulate phagocytosis. The H1 antagonist counteracts the effect of histamine, whereas the H2 antagonist does not. The histamine receptor of Tetrahymena is of H1-type, since it cannot distinguish between histamine and antagonists which are closely related to it chemically. It does, however, distinguish between histamine and the chemically unrelated H1 antagonist, phenindamine. The H2 antagonist does not interact with the receptor.

Original languageEnglish
Pages (from-to)161-163
Number of pages3
JournalActa Biologica et Medica Germanica
Volume37
Issue number1
Publication statusPublished - 1978

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Tetrahymena
Histamine H1 Receptors
Histamine H2 Receptors
Metiamide
Histamine H1 Antagonists
Histamine H2 Antagonists
Tetrahymena pyriformis
Histamine Receptors
Histamine Antagonists
Phagocytosis
Histamine
phenindamine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effects of H1 and H2 receptor antagonists on Tetrahymena. / Csaba, G.; László, V.; Darvas, Z.

In: Acta Biologica et Medica Germanica, Vol. 37, No. 1, 1978, p. 161-163.

Research output: Contribution to journalArticle

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