Effects of histamine on transport (Na+-K+-dependent) ATPase system (EC 3.6.1.3) prepared from human gastric mucosa

G. Mózsik, L. Nagy, F. Tárnok, T. Jávor, J. Kutas

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Abstract

The transport (membrane, Na+-K+-stimulated or Na+-K+-dependent) ATPase (EC 3.6.1.3) was prepared from fundic gastric mucosa of operated patients and the histamine effect was studied on its activity. It has been observed that histamine significantly stimulated the Mg2+-dependent part, on the one hand, and inhibited the total and Na+-K+-dependent ATPase activity from membrane fractions of human gastric mucosa, on the other hand. The interrelationship between the transport ATPase system and the adenyl cyclase system, at the level of the cell membrane, is reviewed.

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalPharmacology
Volume12
Issue number4-5
DOIs
Publication statusPublished - Jan 1 1974

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Keywords

  • Adenyl cyclase system
  • Cell membrane
  • Feed-back mechanisms
  • HCl secretion
  • Histamine effect
  • Human gastric mucosa
  • Transport ATPase system

ASJC Scopus subject areas

  • Pharmacology

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