Effects of hemin, co2, and ph on the branching of candida albicans filamentous forms

Ágnes Jakab, K. Antal, T. Emri, Imre Boczonádi, Alexandra Imre, Eniko Gebri, László Majoros, Walter Péter Pfliegler, Máté Szarka, György Balla, József Balla, István Pócsi

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Morphological transitions of wild-Type and oxidative stress-Tolerant Candida albicans strains were followed in the RPMI-FBS culture medium at pH values and CO2 levels characteristic for the anatomical niches inhabited by this opportunistic human pathogen fungus, including the oral cavity as well as the intestinal and vaginal lumens. Selected cultures were also supplemented with hemin modeling bleedings. Germination as well as elongation and branching of hyphae were monitored in the cultures using time-lapse video microscopy. Unexpectedly, branching time, which is defined as the time taken until the first branch of hypha emerges for the first time after germination, correlated well with alterations in the environmental conditions meanwhile no such correlations were found for germination time (time lasted until the appearance of the germination tube). Based on these observations, hypotheses were set up to estimate the significance of branching time in the pathogenesis of both superficial and systemic candidiases.

Original languageEnglish
Pages (from-to)387-403
Number of pages17
JournalActa microbiologica et immunologica Hungarica
Issue number4
Publication statusPublished - Dec 2016


  • Candida albicans
  • Hemin
  • Hyphal branching
  • Morphological transitions
  • Time-lapse video microscopy

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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