Effects of haloperidol treatment on prolactin response to D- fenfluramine challenge in acute schizophrenia

Pavel Mohr, Jiří Horáček, Lucie Motlová, Jan Libiger, Pál Czobor

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We have previously described an association between higher serotonin (5- HT) responsivity, indexed by prolactin response to D-fenfluramine challenge, and poorer treatment response to haloperidol in non-medicated schizophrenics. The aim of the present study was to investigate the effects of antidopaminergic treatment on the prolactin response in the repeated challenge test. D-Fenfluramine was administered to 22 young, acutely ill schizophrenics (11 females and 11 males) after 4 weeks of haloperidol treatment. Whereas neuroleptic administration significantly raised basal prolactin levels (P < 0.0001), subsequent D-fenfluramine challenge produced an additional significant increase (P < 0.001). Moreover, the magnitude of this increase was not different from the pretreatment response. Our results demonstrate that prolactin response to the challenge is mediated through the 5-HT system. An observed negative association between posttreatment prolactin response and therapeutic response to haloperidol did not reach statistical significance.

Original languageEnglish
Pages (from-to)322-325
Number of pages4
JournalPsychopharmacology
Volume141
Issue number3
DOIs
Publication statusPublished - May 5 1999

Keywords

  • D-Fenfluramine challenge
  • Haloperidol
  • Prolactin
  • Schizophrenia
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology

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