Növekedési hormonnal történó hormonpótló kezelés hatásai súlyos növekedési hormonhiányos felnóttekben.

Translated title of the contribution: Effects of growth hormone replacement therapy in adults with severe growth hormone deficiency

E. Hubina, L. Kovács, I. Szabolcs, E. Rimanóczy, A. Ferencz, S. Czirják, M. Tóth, N. Szücs, K. Rácz, M. Góth

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The aim of the study was to analyse the effects of GH replacement therapy (1 year duration) on body composition, carbohydrate metabolism, thyroid hormone metabolism and bone mineral density in 8 adults with growth hormone deficiency (5 women, 3 men; mean age 40 years). Mean maintenance dose of GH was 1.5 IU/day-1.76 IU/day for women and 1.07 IU/day for men, respectively--determined according to individual patient requirements. Serum insulin-like growth factor-I standard deviation score increased from -5.4 to 0.0 (p <0.001). There was a significant negative relationship between serum insulin-like growth factor-I standard deviation score at the start of therapy and the increase in this score (r = -0.85; p <0.05). The waist:hip ratio decreased after 12 months by 0.039 (p <0.05). The glycosylated hemoglobin increased (4.43 +/- 0.56% vs. 5.86 +/- 0.27; p <0.05), and a negative correlation of the baseline glycosylated hemoglobin to the glycosylated hemoglobin increase was found (r = -0.88; p <0.01). Both the free triiodothyronine and free triiodothyronine:free thyroxine ratio increased (3.09 +/- 0.22 vs. 4.17 +/- 0.40; p <0.05, and 0.234 +/- 0.02 vs. 0.324 +/- 0.04; p <0.01), and a positive relationship was observed between this ratio at the start of therapy and the increase in the ratio (r = 0.76, p <0.05). The bone mineral density of lumbar spine and femoral neck expressed as z-score increased (-1.18 +/- 0.56 vs. -0.75 +/- 0.48; p <0.01 and -0.06 +/- 0.60 vs. 0.43 +/- 0.43; p <0.05), while the bone mineral density of forearm was unchanged. CONCLUSIONS: Growth hormone replacement leads to a decrease in visceral fat, modulates the thyroid hormone levels by increasing peripheral conversion of thyroxine to triiodothyronine and probably is a physiological regulator of peripheral thyroxine metabolism, slightly deteriorates the carbohydrate metabolism, and results in an increase of bone mineral density of lumbar spine and femoral neck.

Original languageHungarian
Pages (from-to)2375-2379
Number of pages5
JournalOrvosi Hetilap
Volume141
Issue number44
Publication statusPublished - Oct 29 2000

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Hormone Replacement Therapy
Bone Density
Growth Hormone
Glycosylated Hemoglobin A
Triiodothyronine
Thyroxine
Femur Neck
Carbohydrate Metabolism
Insulin-Like Growth Factor I
Thyroid Hormones
Spine
Waist-Hip Ratio
Intra-Abdominal Fat
Body Composition
Serum
Forearm
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Növekedési hormonnal történó hormonpótló kezelés hatásai súlyos növekedési hormonhiányos felnóttekben. / Hubina, E.; Kovács, L.; Szabolcs, I.; Rimanóczy, E.; Ferencz, A.; Czirják, S.; Tóth, M.; Szücs, N.; Rácz, K.; Góth, M.

In: Orvosi Hetilap, Vol. 141, No. 44, 29.10.2000, p. 2375-2379.

Research output: Contribution to journalArticle

Hubina, E. ; Kovács, L. ; Szabolcs, I. ; Rimanóczy, E. ; Ferencz, A. ; Czirják, S. ; Tóth, M. ; Szücs, N. ; Rácz, K. ; Góth, M. / Növekedési hormonnal történó hormonpótló kezelés hatásai súlyos növekedési hormonhiányos felnóttekben. In: Orvosi Hetilap. 2000 ; Vol. 141, No. 44. pp. 2375-2379.
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title = "N{\"o}veked{\'e}si hormonnal t{\"o}rt{\'e}n{\'o} hormonp{\'o}tl{\'o} kezel{\'e}s hat{\'a}sai s{\'u}lyos n{\"o}veked{\'e}si hormonhi{\'a}nyos feln{\'o}ttekben.",
abstract = "The aim of the study was to analyse the effects of GH replacement therapy (1 year duration) on body composition, carbohydrate metabolism, thyroid hormone metabolism and bone mineral density in 8 adults with growth hormone deficiency (5 women, 3 men; mean age 40 years). Mean maintenance dose of GH was 1.5 IU/day-1.76 IU/day for women and 1.07 IU/day for men, respectively--determined according to individual patient requirements. Serum insulin-like growth factor-I standard deviation score increased from -5.4 to 0.0 (p <0.001). There was a significant negative relationship between serum insulin-like growth factor-I standard deviation score at the start of therapy and the increase in this score (r = -0.85; p <0.05). The waist:hip ratio decreased after 12 months by 0.039 (p <0.05). The glycosylated hemoglobin increased (4.43 +/- 0.56{\%} vs. 5.86 +/- 0.27; p <0.05), and a negative correlation of the baseline glycosylated hemoglobin to the glycosylated hemoglobin increase was found (r = -0.88; p <0.01). Both the free triiodothyronine and free triiodothyronine:free thyroxine ratio increased (3.09 +/- 0.22 vs. 4.17 +/- 0.40; p <0.05, and 0.234 +/- 0.02 vs. 0.324 +/- 0.04; p <0.01), and a positive relationship was observed between this ratio at the start of therapy and the increase in the ratio (r = 0.76, p <0.05). The bone mineral density of lumbar spine and femoral neck expressed as z-score increased (-1.18 +/- 0.56 vs. -0.75 +/- 0.48; p <0.01 and -0.06 +/- 0.60 vs. 0.43 +/- 0.43; p <0.05), while the bone mineral density of forearm was unchanged. CONCLUSIONS: Growth hormone replacement leads to a decrease in visceral fat, modulates the thyroid hormone levels by increasing peripheral conversion of thyroxine to triiodothyronine and probably is a physiological regulator of peripheral thyroxine metabolism, slightly deteriorates the carbohydrate metabolism, and results in an increase of bone mineral density of lumbar spine and femoral neck.",
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T1 - Növekedési hormonnal történó hormonpótló kezelés hatásai súlyos növekedési hormonhiányos felnóttekben.

AU - Hubina, E.

AU - Kovács, L.

AU - Szabolcs, I.

AU - Rimanóczy, E.

AU - Ferencz, A.

AU - Czirják, S.

AU - Tóth, M.

AU - Szücs, N.

AU - Rácz, K.

AU - Góth, M.

PY - 2000/10/29

Y1 - 2000/10/29

N2 - The aim of the study was to analyse the effects of GH replacement therapy (1 year duration) on body composition, carbohydrate metabolism, thyroid hormone metabolism and bone mineral density in 8 adults with growth hormone deficiency (5 women, 3 men; mean age 40 years). Mean maintenance dose of GH was 1.5 IU/day-1.76 IU/day for women and 1.07 IU/day for men, respectively--determined according to individual patient requirements. Serum insulin-like growth factor-I standard deviation score increased from -5.4 to 0.0 (p <0.001). There was a significant negative relationship between serum insulin-like growth factor-I standard deviation score at the start of therapy and the increase in this score (r = -0.85; p <0.05). The waist:hip ratio decreased after 12 months by 0.039 (p <0.05). The glycosylated hemoglobin increased (4.43 +/- 0.56% vs. 5.86 +/- 0.27; p <0.05), and a negative correlation of the baseline glycosylated hemoglobin to the glycosylated hemoglobin increase was found (r = -0.88; p <0.01). Both the free triiodothyronine and free triiodothyronine:free thyroxine ratio increased (3.09 +/- 0.22 vs. 4.17 +/- 0.40; p <0.05, and 0.234 +/- 0.02 vs. 0.324 +/- 0.04; p <0.01), and a positive relationship was observed between this ratio at the start of therapy and the increase in the ratio (r = 0.76, p <0.05). The bone mineral density of lumbar spine and femoral neck expressed as z-score increased (-1.18 +/- 0.56 vs. -0.75 +/- 0.48; p <0.01 and -0.06 +/- 0.60 vs. 0.43 +/- 0.43; p <0.05), while the bone mineral density of forearm was unchanged. CONCLUSIONS: Growth hormone replacement leads to a decrease in visceral fat, modulates the thyroid hormone levels by increasing peripheral conversion of thyroxine to triiodothyronine and probably is a physiological regulator of peripheral thyroxine metabolism, slightly deteriorates the carbohydrate metabolism, and results in an increase of bone mineral density of lumbar spine and femoral neck.

AB - The aim of the study was to analyse the effects of GH replacement therapy (1 year duration) on body composition, carbohydrate metabolism, thyroid hormone metabolism and bone mineral density in 8 adults with growth hormone deficiency (5 women, 3 men; mean age 40 years). Mean maintenance dose of GH was 1.5 IU/day-1.76 IU/day for women and 1.07 IU/day for men, respectively--determined according to individual patient requirements. Serum insulin-like growth factor-I standard deviation score increased from -5.4 to 0.0 (p <0.001). There was a significant negative relationship between serum insulin-like growth factor-I standard deviation score at the start of therapy and the increase in this score (r = -0.85; p <0.05). The waist:hip ratio decreased after 12 months by 0.039 (p <0.05). The glycosylated hemoglobin increased (4.43 +/- 0.56% vs. 5.86 +/- 0.27; p <0.05), and a negative correlation of the baseline glycosylated hemoglobin to the glycosylated hemoglobin increase was found (r = -0.88; p <0.01). Both the free triiodothyronine and free triiodothyronine:free thyroxine ratio increased (3.09 +/- 0.22 vs. 4.17 +/- 0.40; p <0.05, and 0.234 +/- 0.02 vs. 0.324 +/- 0.04; p <0.01), and a positive relationship was observed between this ratio at the start of therapy and the increase in the ratio (r = 0.76, p <0.05). The bone mineral density of lumbar spine and femoral neck expressed as z-score increased (-1.18 +/- 0.56 vs. -0.75 +/- 0.48; p <0.01 and -0.06 +/- 0.60 vs. 0.43 +/- 0.43; p <0.05), while the bone mineral density of forearm was unchanged. CONCLUSIONS: Growth hormone replacement leads to a decrease in visceral fat, modulates the thyroid hormone levels by increasing peripheral conversion of thyroxine to triiodothyronine and probably is a physiological regulator of peripheral thyroxine metabolism, slightly deteriorates the carbohydrate metabolism, and results in an increase of bone mineral density of lumbar spine and femoral neck.

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