The effects of oral glutaurine (gamma-L-glutamyl-taurine, LitoralonR Chinoin, Budapest) treatment on electroconvulsive shock-induced amnesia were studied. Oral treatment with glutaurine in a dose of 1-20 μg was ineffective on electroshock-induced amnesia if the treatment was applied before the electroconvulsive shock. Fifty μg given in the same experimental paradigm could attenuate the amnesia considerably. When the treatment with glutaurine was applied immediately after the electroconvulsive shock, even 1 and 10 μg doses were effective in attenuating the amnesia in both the 24h and 48h retestings. However when glutaurine was given one hour before the 24h and 48h retestings, it proved to be ineffective. The data indicate that glutaurine is able to prevent electroconvulsive shock-induced amnesia by counteracting the effect of the electroconvulsive shock on the memory consolidation phase, but it is less effective on learning or it is ineffective on retrieval processes.
ASJC Scopus subject areas
- Endocrine and Autonomic Systems
- Cellular and Molecular Neuroscience