Effects of genetic vs. environmental factors on cardiovascular autonomic function: A twin study

J. Osztovits, T. Horváth, L. Littvay, R. Steinbach, Á Jermendy, Á Tárnoki, D. Tárnoki, J. Métneki, M. Kollai, G. Jermendy

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aims Cardiovascular autonomic function is often assessed in patients with diabetes by measuring heart rate variability and baroreflex sensitivity, the heritability of which is not fully understood. The present study was aimed to determine the effects of genetic and environmental factors on heart rate variability and baroreflex sensitivity in monozygotic and dizygotic adult healthy twin pairs. Methods A total of 101 (63 monozygotic, 38 dizygotic) adult twin pairs (n=202; mean age 44.3years) were investigated. Anthropometric variables and serum metabolic markers were measured, while environmental characteristics were evaluated by questionnaires. Linear and spectral indices of heart rate variability and baroreflex sensitivity were determined by non-invasive methods. All measurements were adjusted for age and gender (model1) and for all significantly relevant covariates (model2). Heritability A-C-E structural equation models were used for characterizing the proportion of additive genetic, shared and unshared environmental influences. Results Genetic influence of different cardiovascular autonomic indices was estimated between 10.3 and 39.4%, common environmental influence was found between 0.0 and 33.2%, while unshared environmental influence was observed between 60.6 and 81.4% in model1 analysis. In multivariable-adjusted heritability estimates (model2), the magnitude of the genetic effects decreased to 0.0%, common environmental influence was nearly unchanged (values between 4.4 and 14.5%), while unshared environmental influence slightly increased (values between 85.5 and 96.5%). Conclusions Unshared environmental but not genetic factors have substantial influence on cardiovascular autonomic function, suggesting that appropriate treatment of all modifiable environmental factors is of importance in order to prevent or ameliorate cardiovascular autonomic neuropathy.

Original languageEnglish
Pages (from-to)1241-1248
Number of pages8
JournalDiabetic Medicine
Volume28
Issue number10
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Twin Studies
Baroreflex
Heart Rate
Dizygotic Twins
Structural Models
Biomarkers
Therapeutics

Keywords

  • Baroreflex sensitivity
  • Cardiovascular autonomic function
  • Cardiovascular autonomic neuropathy
  • Heart rate variability
  • Twin study

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Effects of genetic vs. environmental factors on cardiovascular autonomic function : A twin study. / Osztovits, J.; Horváth, T.; Littvay, L.; Steinbach, R.; Jermendy, Á; Tárnoki, Á; Tárnoki, D.; Métneki, J.; Kollai, M.; Jermendy, G.

In: Diabetic Medicine, Vol. 28, No. 10, 10.2011, p. 1241-1248.

Research output: Contribution to journalArticle

Osztovits, J. ; Horváth, T. ; Littvay, L. ; Steinbach, R. ; Jermendy, Á ; Tárnoki, Á ; Tárnoki, D. ; Métneki, J. ; Kollai, M. ; Jermendy, G. / Effects of genetic vs. environmental factors on cardiovascular autonomic function : A twin study. In: Diabetic Medicine. 2011 ; Vol. 28, No. 10. pp. 1241-1248.
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abstract = "Aims Cardiovascular autonomic function is often assessed in patients with diabetes by measuring heart rate variability and baroreflex sensitivity, the heritability of which is not fully understood. The present study was aimed to determine the effects of genetic and environmental factors on heart rate variability and baroreflex sensitivity in monozygotic and dizygotic adult healthy twin pairs. Methods A total of 101 (63 monozygotic, 38 dizygotic) adult twin pairs (n=202; mean age 44.3years) were investigated. Anthropometric variables and serum metabolic markers were measured, while environmental characteristics were evaluated by questionnaires. Linear and spectral indices of heart rate variability and baroreflex sensitivity were determined by non-invasive methods. All measurements were adjusted for age and gender (model1) and for all significantly relevant covariates (model2). Heritability A-C-E structural equation models were used for characterizing the proportion of additive genetic, shared and unshared environmental influences. Results Genetic influence of different cardiovascular autonomic indices was estimated between 10.3 and 39.4{\%}, common environmental influence was found between 0.0 and 33.2{\%}, while unshared environmental influence was observed between 60.6 and 81.4{\%} in model1 analysis. In multivariable-adjusted heritability estimates (model2), the magnitude of the genetic effects decreased to 0.0{\%}, common environmental influence was nearly unchanged (values between 4.4 and 14.5{\%}), while unshared environmental influence slightly increased (values between 85.5 and 96.5{\%}). Conclusions Unshared environmental but not genetic factors have substantial influence on cardiovascular autonomic function, suggesting that appropriate treatment of all modifiable environmental factors is of importance in order to prevent or ameliorate cardiovascular autonomic neuropathy.",
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AU - Horváth, T.

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AU - Steinbach, R.

AU - Jermendy, Á

AU - Tárnoki, Á

AU - Tárnoki, D.

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AU - Jermendy, G.

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N2 - Aims Cardiovascular autonomic function is often assessed in patients with diabetes by measuring heart rate variability and baroreflex sensitivity, the heritability of which is not fully understood. The present study was aimed to determine the effects of genetic and environmental factors on heart rate variability and baroreflex sensitivity in monozygotic and dizygotic adult healthy twin pairs. Methods A total of 101 (63 monozygotic, 38 dizygotic) adult twin pairs (n=202; mean age 44.3years) were investigated. Anthropometric variables and serum metabolic markers were measured, while environmental characteristics were evaluated by questionnaires. Linear and spectral indices of heart rate variability and baroreflex sensitivity were determined by non-invasive methods. All measurements were adjusted for age and gender (model1) and for all significantly relevant covariates (model2). Heritability A-C-E structural equation models were used for characterizing the proportion of additive genetic, shared and unshared environmental influences. Results Genetic influence of different cardiovascular autonomic indices was estimated between 10.3 and 39.4%, common environmental influence was found between 0.0 and 33.2%, while unshared environmental influence was observed between 60.6 and 81.4% in model1 analysis. In multivariable-adjusted heritability estimates (model2), the magnitude of the genetic effects decreased to 0.0%, common environmental influence was nearly unchanged (values between 4.4 and 14.5%), while unshared environmental influence slightly increased (values between 85.5 and 96.5%). Conclusions Unshared environmental but not genetic factors have substantial influence on cardiovascular autonomic function, suggesting that appropriate treatment of all modifiable environmental factors is of importance in order to prevent or ameliorate cardiovascular autonomic neuropathy.

AB - Aims Cardiovascular autonomic function is often assessed in patients with diabetes by measuring heart rate variability and baroreflex sensitivity, the heritability of which is not fully understood. The present study was aimed to determine the effects of genetic and environmental factors on heart rate variability and baroreflex sensitivity in monozygotic and dizygotic adult healthy twin pairs. Methods A total of 101 (63 monozygotic, 38 dizygotic) adult twin pairs (n=202; mean age 44.3years) were investigated. Anthropometric variables and serum metabolic markers were measured, while environmental characteristics were evaluated by questionnaires. Linear and spectral indices of heart rate variability and baroreflex sensitivity were determined by non-invasive methods. All measurements were adjusted for age and gender (model1) and for all significantly relevant covariates (model2). Heritability A-C-E structural equation models were used for characterizing the proportion of additive genetic, shared and unshared environmental influences. Results Genetic influence of different cardiovascular autonomic indices was estimated between 10.3 and 39.4%, common environmental influence was found between 0.0 and 33.2%, while unshared environmental influence was observed between 60.6 and 81.4% in model1 analysis. In multivariable-adjusted heritability estimates (model2), the magnitude of the genetic effects decreased to 0.0%, common environmental influence was nearly unchanged (values between 4.4 and 14.5%), while unshared environmental influence slightly increased (values between 85.5 and 96.5%). Conclusions Unshared environmental but not genetic factors have substantial influence on cardiovascular autonomic function, suggesting that appropriate treatment of all modifiable environmental factors is of importance in order to prevent or ameliorate cardiovascular autonomic neuropathy.

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KW - Cardiovascular autonomic neuropathy

KW - Heart rate variability

KW - Twin study

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