Effects of free mobilization and low- to high-intensity treadmill running on the immobilization-induced bone loss in rats

Pekka Kannus, Harri Sievänen, Teppo L N Järvinen, Markku Järvinen, Martti Kvist, Pekka Oja, Ilkka Vuori, L. Józsa

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

After an immobilization period of 3 weeks, the effects of free remobilization (8 weeks) as well as low- and high-intensity treadmill running on the bone mineral content (BMC) and density (BMD) of the hindlimbs of Sprague-Dawley rats (n = 70) were studied using a dual-energy x-ray absorptiometric scanner. In the low-intensity running program, the rats were allowed to move freely in the cage for 1 week, after which they started to run on a treadmill twice a day for 7 weeks. The speed of the treadmill was 20 cm/s, with an uphill inclination of 10°. The running time was gradually increased from 20 minutes per session to 45 minutes per session. In the high- intensity group, the program was similar, with the exception that the speed of the treadmill was 30 cm/s, with an uphill inclination of 30°. Immobilization for 3 weeks produced a significant BMC and BMD loss in the immobilized left femur and tibia (mean loss 9.6%, p <0.001) but did not affect the right free limbs. Both low- and high-intensity running restored mineral content in the immobilized limb; however, an average 5% difference (p <0.05) in mineral content of the right and left limb bones persisted. In the running groups, the values for the immobilized left limbs were at the same level or exceeded (range 3.8-11.6%, p <0.05-0.01) and those of the free right limbs exclusively exceeded (range 5.3-15.9%, p <0.05-0.01) the corresponding values of the age-matched control rats. In the group with free remobilization, the BMCs and BMDs always remained below those in the controls (range -3.2 to -12.6%, p values ranging from NS to p <0.01). Thus, this study showed the need for greater than normal activity to restore the BMC and BMD from disuse to normal.

Original languageEnglish
Pages (from-to)1613-1619
Number of pages7
JournalJournal of Bone and Mineral Research
Volume9
Issue number10
Publication statusPublished - Oct 1994

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Running
Immobilization
Bone Density
Extremities
Bone and Bones
Minerals
Hindlimb
Tibia
Femur
Sprague Dawley Rats
X-Rays

ASJC Scopus subject areas

  • Surgery

Cite this

Effects of free mobilization and low- to high-intensity treadmill running on the immobilization-induced bone loss in rats. / Kannus, Pekka; Sievänen, Harri; Järvinen, Teppo L N; Järvinen, Markku; Kvist, Martti; Oja, Pekka; Vuori, Ilkka; Józsa, L.

In: Journal of Bone and Mineral Research, Vol. 9, No. 10, 10.1994, p. 1613-1619.

Research output: Contribution to journalArticle

Kannus, P, Sievänen, H, Järvinen, TLN, Järvinen, M, Kvist, M, Oja, P, Vuori, I & Józsa, L 1994, 'Effects of free mobilization and low- to high-intensity treadmill running on the immobilization-induced bone loss in rats', Journal of Bone and Mineral Research, vol. 9, no. 10, pp. 1613-1619.
Kannus, Pekka ; Sievänen, Harri ; Järvinen, Teppo L N ; Järvinen, Markku ; Kvist, Martti ; Oja, Pekka ; Vuori, Ilkka ; Józsa, L. / Effects of free mobilization and low- to high-intensity treadmill running on the immobilization-induced bone loss in rats. In: Journal of Bone and Mineral Research. 1994 ; Vol. 9, No. 10. pp. 1613-1619.
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abstract = "After an immobilization period of 3 weeks, the effects of free remobilization (8 weeks) as well as low- and high-intensity treadmill running on the bone mineral content (BMC) and density (BMD) of the hindlimbs of Sprague-Dawley rats (n = 70) were studied using a dual-energy x-ray absorptiometric scanner. In the low-intensity running program, the rats were allowed to move freely in the cage for 1 week, after which they started to run on a treadmill twice a day for 7 weeks. The speed of the treadmill was 20 cm/s, with an uphill inclination of 10°. The running time was gradually increased from 20 minutes per session to 45 minutes per session. In the high- intensity group, the program was similar, with the exception that the speed of the treadmill was 30 cm/s, with an uphill inclination of 30°. Immobilization for 3 weeks produced a significant BMC and BMD loss in the immobilized left femur and tibia (mean loss 9.6{\%}, p <0.001) but did not affect the right free limbs. Both low- and high-intensity running restored mineral content in the immobilized limb; however, an average 5{\%} difference (p <0.05) in mineral content of the right and left limb bones persisted. In the running groups, the values for the immobilized left limbs were at the same level or exceeded (range 3.8-11.6{\%}, p <0.05-0.01) and those of the free right limbs exclusively exceeded (range 5.3-15.9{\%}, p <0.05-0.01) the corresponding values of the age-matched control rats. In the group with free remobilization, the BMCs and BMDs always remained below those in the controls (range -3.2 to -12.6{\%}, p values ranging from NS to p <0.01). Thus, this study showed the need for greater than normal activity to restore the BMC and BMD from disuse to normal.",
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