Effects of fluvastatin and coenzyme Q10 on skeletal muscle in normo- and hypercholesterolaemic rats

J. Vincze, Jenes, M. Füzi, J. Almássy, R. Németh, G. Szigeti, B. Dienes, Z. Gaál, P. Szentesi, I. Jóna, P. Kertai, G. Paragh, L. Csernoch

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Myalgia and muscle weakness may appreciably contribute to the poor adherence to statin therapy. Although the pathomechanism of statin-induced myopathy is not completely understood, changes in calcium homeostasis and reduced coenzyme Q10 levels are hypothesized to play important roles. In our experiments, fluvastatin and/or coenzyme Q10 was administered chronically to normocholesterolaemic or hypercholaestherolaemic rats, and the modifications of the calcium homeostasis and the strength of their muscles were investigated. While hypercholesterolaemia did not change the frequency of sparks, fluvastatin increased it on muscles both from normocholesterolaemic and from hypercholesterolaemic rats. This effect, however, was not mediated by a chronic modification of the ryanodine receptor as shown by the unchanged ryanodine binding in the latter group. While coenzyme Q10 supplementation significantly reduced the frequency of the spontaneous calcium release events, it did not affect their amplitude and spatial spread in muscles from fluvastatin-treated rats. This indicates that coenzyme Q10 supplementation prevented the spark frequency increasing effect of fluvastatin without having a major effect on the amount of calcium released during individual sparks. In conclusion, we have found that fluvastatin, independently of the cholesterol level in the blood, consistently and specifically increased the frequency of calcium sparks in skeletal muscle cells, an effect which could be prevented by the addition of coenzyme Q10 to the diet. These results support theories favouring the role of calcium handling in the pathophysiology of statin-induced myopathy and provide a possible pathway for the protective effect of coenzyme Q10 in statin treated patients symptomatic of this condition.

Original languageEnglish
Pages (from-to)263-274
Number of pages12
JournalJournal of Muscle Research and Cell Motility
Volume36
Issue number3
DOIs
Publication statusPublished - Apr 29 2015

Fingerprint

coenzyme Q10
fluvastatin
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Muscle
Rats
Skeletal Muscle
Calcium
Electric sparks
Muscular Diseases
Homeostasis
Ryanodine
Muscles
Ryanodine Receptor Calcium Release Channel
Calcium Signaling
Myalgia
Muscle Weakness
Muscle Strength
Hypercholesterolemia
Muscle Cells
Nutrition

Keywords

  • Calcium homeostase
  • Force
  • Myopathy
  • Q<inf>10</inf>
  • Skeletal muscle
  • Spark
  • Statin

ASJC Scopus subject areas

  • Physiology
  • Cell Biology
  • Biochemistry

Cite this

Effects of fluvastatin and coenzyme Q10 on skeletal muscle in normo- and hypercholesterolaemic rats. / Vincze, J.; Jenes; Füzi, M.; Almássy, J.; Németh, R.; Szigeti, G.; Dienes, B.; Gaál, Z.; Szentesi, P.; Jóna, I.; Kertai, P.; Paragh, G.; Csernoch, L.

In: Journal of Muscle Research and Cell Motility, Vol. 36, No. 3, 29.04.2015, p. 263-274.

Research output: Contribution to journalArticle

Vincze, J. ; Jenes ; Füzi, M. ; Almássy, J. ; Németh, R. ; Szigeti, G. ; Dienes, B. ; Gaál, Z. ; Szentesi, P. ; Jóna, I. ; Kertai, P. ; Paragh, G. ; Csernoch, L. / Effects of fluvastatin and coenzyme Q10 on skeletal muscle in normo- and hypercholesterolaemic rats. In: Journal of Muscle Research and Cell Motility. 2015 ; Vol. 36, No. 3. pp. 263-274.
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AU - Németh, R.

AU - Szigeti, G.

AU - Dienes, B.

AU - Gaál, Z.

AU - Szentesi, P.

AU - Jóna, I.

AU - Kertai, P.

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