Effects of fasting, intermittent feeding, or continuous parenteral nutrition on rat liver and brain energy metabolism as assessed by 31P-NMR

Gyorgy Bodoky, Zhong Jin Yang, Michael M. Meguid, Alessandro Laviano, Nikolaus Szeverenyi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We wanted to determine what happens to brain PCr and ATP relative to that in liver during a series of dietary manipulation consisting of a severe fast, during eating (when nutrients are intermittently supplied), and during and after PN-100, when an excess amount of nutrients are continuously supplied, using 31P-NMR spectroscopy, in rats randomized to a Fast or Fed group in which energy was provided either as chow or as PN-100. Liver ATP concentration, and brain and liver 31P-nuclear magnetic resonance (NMR) spectras were measured serially. Brain energy metabolism was not different between groups and among days. In contrast, Fasted group showed increased liver ATP/Pi ratio and decreased ATP concentration and ATP/phosphomonoester ratio, there being no difference between Fed and PN-100 groups. Data suggest that brain energy metabolism is maintained regardless of whether energy is supplied intermittently or continuously, and during a negative caloric intake period, brain energy metabolism is quantitatively preserved, suggesting that ATP production by liver is subservient to brain ATP state.

Original languageEnglish
Pages (from-to)521-527
Number of pages7
JournalPhysiology and Behavior
Volume58
Issue number3
DOIs
Publication statusPublished - Sep 1995

Keywords

  • ATP
  • Brain
  • Fasted
  • Fed
  • Liver
  • P-NMR
  • PCr
  • PN
  • Pi
  • Rat

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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