Effects of extracerebral dopamine on salsolinol- or thyrotropin-releasing hormone-induced prolactin (PRL) secretion in goats

Yuki Inaba, Yuki Kato, Azumi Itou, Aoi Chiba, Ken Sawai, F. Fülöp, György Miklos Nagy, Tsutomu Hashizume

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of the present study was to clarify the effect of extracerebral dopamine (DA) on salsolinol (SAL)-induced prolactin (PRL) secretion in goats. An intravenous injection of SAL or thyrotropin-releasing hormone (TRH) was given to female goats before and after treatment with an extracerebral DA receptor antagonist, domperidone (DOM), and the PRL-releasing response to SAL was compared with that to TRH. DOM alone increased plasma PRL concentrations and the PRL-releasing response to DOM alone was greater than that to either SAL alone or TRH alone. The PRL-releasing response to DOM plus SAL was similar to that to DOM alone, and no additive effect of DOM and SAL on the secretion of PRL was observed. In contrast, the PRL-releasing response to DOM plus TRH was greater than that to either TRH alone or DOM alone and DOM synergistically increased TRH-induced PRL secretion. The present results demonstrate that the mechanism involved in PRL secretion by SAL differs from that by TRH, and suggest that the extracerebral DA might be associated in part with the modulation of SAL-induced PRL secretion in goats.

Original languageEnglish
Pages (from-to)1522-1527
Number of pages6
JournalAnimal Science Journal
Volume87
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

Fingerprint

thyrotropin-releasing hormone
Domperidone
Thyrotropin-Releasing Hormone
prolactin
dopamine
Goats
Prolactin
Dopamine
goats
secretion
salsolinol
Dopamine Antagonists
additive effect
intravenous injection
Intravenous Injections
antagonists

Keywords

  • domperidone
  • dopamine
  • prolactin
  • salsolinol
  • TRH

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Effects of extracerebral dopamine on salsolinol- or thyrotropin-releasing hormone-induced prolactin (PRL) secretion in goats. / Inaba, Yuki; Kato, Yuki; Itou, Azumi; Chiba, Aoi; Sawai, Ken; Fülöp, F.; Nagy, György Miklos; Hashizume, Tsutomu.

In: Animal Science Journal, Vol. 87, No. 12, 01.12.2016, p. 1522-1527.

Research output: Contribution to journalArticle

Inaba, Yuki ; Kato, Yuki ; Itou, Azumi ; Chiba, Aoi ; Sawai, Ken ; Fülöp, F. ; Nagy, György Miklos ; Hashizume, Tsutomu. / Effects of extracerebral dopamine on salsolinol- or thyrotropin-releasing hormone-induced prolactin (PRL) secretion in goats. In: Animal Science Journal. 2016 ; Vol. 87, No. 12. pp. 1522-1527.
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