Effects of excitotoxic lesions of the substantia innominata, ventral and dorsal globus pallidus on visual discrimination acquisition, performance and reversal in the rat

J. L. Evenden, H. M. Marston, G. H. Jones, V. Giardini, L. Lénárd, B. J. Everitt, T. W. Robbins

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Rats received infusions of ibotenic acid into the substantia innominata, in the region of the nucleus basalis of Meynert (nbM), before and after training on simple (simultaneous) and conditional visual discriminations. The iboteanate infusions reduced cortical choline acetyltransferase (ChAT) levels by about 20%, destroyed many ChAT-immunoreactive neurons in the nbM, but also caused the loss of many neurons in the substantia innominata and adjacent areas. These lesions did not impair the acquisition and performance of a simple visual discrimination, but did impair reversal of the discrimination and the performance of a conditional visual discrimination. However, the degree of impairment was unrelated to the degree of cortical ChAT loss. Ibotenic acid lesions to the dorsal globus pallidus also impaired reversal of discrimination but left acquisition and performance unaffected. Striatal, dopamine depletion produced by 6-hydroxydopamine (6-OHDA) infusions into the mid-ventral caudate nucleus impaired performance of the simultaneous visual discrimination. Cortical noradrenaline depletion produced by 6-OHDA lesions of the dorsal noradrenergic bundle either alone or in combination with ibotenic acid lesions of the substantia innominata had no effect on acquisition of the discrimination. It is concluded that ibotenic acid lesions of the substantia innominata or to the dorsal globus pallidus affect learning and performance of conditional visual discrimination performance and impair reversal learning without affecting the capacity to discriminate visual events. These results are compared to those following cortical noradrenaline depletion or striatal dopamine loss.

Original languageEnglish
Pages (from-to)129-149
Number of pages21
JournalBehavioural Brain Research
Volume32
Issue number2
DOIs
Publication statusPublished - Mar 1 1989

Fingerprint

Substantia Innominata
Globus Pallidus
Ibotenic Acid
Choline O-Acetyltransferase
Oxidopamine
Basal Nucleus of Meynert
Corpus Striatum
Dopamine
Norepinephrine
Reversal Learning
Neurons
Discrimination (Psychology)
Caudate Nucleus
Learning

Keywords

  • Acetylcholine
  • Globus pallidus
  • Learning
  • Memory
  • Nucleus basalis of Meynert
  • Substantia innominata
  • Visual discrimination

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Effects of excitotoxic lesions of the substantia innominata, ventral and dorsal globus pallidus on visual discrimination acquisition, performance and reversal in the rat. / Evenden, J. L.; Marston, H. M.; Jones, G. H.; Giardini, V.; Lénárd, L.; Everitt, B. J.; Robbins, T. W.

In: Behavioural Brain Research, Vol. 32, No. 2, 01.03.1989, p. 129-149.

Research output: Contribution to journalArticle

Evenden, J. L. ; Marston, H. M. ; Jones, G. H. ; Giardini, V. ; Lénárd, L. ; Everitt, B. J. ; Robbins, T. W. / Effects of excitotoxic lesions of the substantia innominata, ventral and dorsal globus pallidus on visual discrimination acquisition, performance and reversal in the rat. In: Behavioural Brain Research. 1989 ; Vol. 32, No. 2. pp. 129-149.
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