Effects of excipients on the tensile strength, surface properties and free volume of Klucel® free films of pharmaceutical importance

Mihály Gottnek, Károly Süvegh, Klára Pintye-Hódi, Géza Regdon

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The physicochemical properties of polymers planned to be applied as mucoadhesive films were studied. Two types of Klucel® hydroxypropylcellulose (LF and MF) were used as film-forming polymers. Hydroxypropylcellulose was incorporated in 2w/w% with glycerol and xylitol as excipients and lidocaine base as an active ingredient at 5, 10 or 15w/w% of the mass of the film-forming polymer. The free volume changes of the films were investigated by positron annihilation lifetime spectroscopy, the mechanical properties of the samples were measured with a tensile strength tester and contact angles were determined to assess the surface properties of the films. It was found that the Klucel® MF films had better physicochemical properties than those of the LF films. Klucel® MF as a film-forming polymer with lidocaine base and both excipients at 5w/w% exhibited physicochemical properties and good workability. The excipients proved to exert strong effects on the physicochemical properties of the tested systems and it is very important to study them intensively in preformulation studies in the pharmaceutical technology in order to utilise their benefits and to avoid any disadvantageous effects.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalRadiation Physics and Chemistry
Volume89
DOIs
Publication statusPublished - Aug 1 2013

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Keywords

  • Free films
  • Free volume
  • Glycerol
  • Hydroxypropylcellulose
  • Positron annihilation lifetime spectroscopy
  • Xylitol

ASJC Scopus subject areas

  • Radiation

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