Effects of erythromycin on the propulsive motility of upper gastrointestinal tract in rats

O. Karadi, B. Bodis, G. Mózsik

Research output: Contribution to journalArticle

Abstract

The differences between the postprandial mixing or propulsion and the interdigestive motility of the gastrointestinal (GI) tract are already known. Earlier studies showed dose-dependent differences in the effects of erythromycin on interdigestive motility. The various GI side-effects (vomiting, diarrhoea) also suggest that there are different effects of erythromycin on the GI motility. The aim of our study was to examine postprandially the propulsive effects of different doses of erythromycin on the movement of intraluminal contents in the upper GI tract of the rat. The animals were fasted for 24 h before the experiments but water was given freely. The rats received 1.5 ml 1.5% methylcellulose painted with 0.05% phenol-red intragastrically (test solution). Erythromycin (E. lactobionate) was given intravenously at doses of 0.05, 0.1, 0.25, 0.5, 1.0 and 5.0 mg/kg 15 min before the administration of a test solution. The animals were sacrificed 20, 60 and 120 min after administration of methylcellulose, when the distance between the front of the painted intraluminal contents and the pylorus was measured and expressed as a percentage of the total length of small intestine. The phenol-red content in the stomach and small intestine was measured spectrophotometrically and the gastric emptying was calculated from the ratio of the measured total and intestinal phenol-red content. Our results showed that the small doses of erythromycin (0.1 and 0.25 mg/kg) accelerated gastric emptying after 20 min but did not change significantly the propulsive motility of upper small intestine; however, large doses of erythromycin (1.0 and 5.0 mg/kg) decreased gastric emptying and upper GI motility after 20 and 60 min. In summary, the prokinetic action of small doses of erythromycin was demonstrated, but its effect-time on GI motility is short and the ratio of the stimulating and inhibitory doses is 1:10.

Original languageEnglish
Pages (from-to)77-82
Number of pages6
JournalInflammopharmacology
Volume5
Issue number1
Publication statusPublished - 1997

Fingerprint

Upper Gastrointestinal Tract
Erythromycin
Phenolsulfonphthalein
Gastrointestinal Motility
Gastric Emptying
Small Intestine
Methylcellulose
Gastrointestinal Contents
Pylorus
Vomiting
Gastrointestinal Tract
Diarrhea
Water

Keywords

  • erythromycin
  • gastrointestinal tract
  • postprandial propulsive motility

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Effects of erythromycin on the propulsive motility of upper gastrointestinal tract in rats. / Karadi, O.; Bodis, B.; Mózsik, G.

In: Inflammopharmacology, Vol. 5, No. 1, 1997, p. 77-82.

Research output: Contribution to journalArticle

@article{239d8f24cb634de7bb57b4933888f664,
title = "Effects of erythromycin on the propulsive motility of upper gastrointestinal tract in rats",
abstract = "The differences between the postprandial mixing or propulsion and the interdigestive motility of the gastrointestinal (GI) tract are already known. Earlier studies showed dose-dependent differences in the effects of erythromycin on interdigestive motility. The various GI side-effects (vomiting, diarrhoea) also suggest that there are different effects of erythromycin on the GI motility. The aim of our study was to examine postprandially the propulsive effects of different doses of erythromycin on the movement of intraluminal contents in the upper GI tract of the rat. The animals were fasted for 24 h before the experiments but water was given freely. The rats received 1.5 ml 1.5{\%} methylcellulose painted with 0.05{\%} phenol-red intragastrically (test solution). Erythromycin (E. lactobionate) was given intravenously at doses of 0.05, 0.1, 0.25, 0.5, 1.0 and 5.0 mg/kg 15 min before the administration of a test solution. The animals were sacrificed 20, 60 and 120 min after administration of methylcellulose, when the distance between the front of the painted intraluminal contents and the pylorus was measured and expressed as a percentage of the total length of small intestine. The phenol-red content in the stomach and small intestine was measured spectrophotometrically and the gastric emptying was calculated from the ratio of the measured total and intestinal phenol-red content. Our results showed that the small doses of erythromycin (0.1 and 0.25 mg/kg) accelerated gastric emptying after 20 min but did not change significantly the propulsive motility of upper small intestine; however, large doses of erythromycin (1.0 and 5.0 mg/kg) decreased gastric emptying and upper GI motility after 20 and 60 min. In summary, the prokinetic action of small doses of erythromycin was demonstrated, but its effect-time on GI motility is short and the ratio of the stimulating and inhibitory doses is 1:10.",
keywords = "erythromycin, gastrointestinal tract, postprandial propulsive motility",
author = "O. Karadi and B. Bodis and G. M{\'o}zsik",
year = "1997",
language = "English",
volume = "5",
pages = "77--82",
journal = "Inflammopharmacology",
issn = "0925-4692",
publisher = "Birkhauser Verlag Basel",
number = "1",

}

TY - JOUR

T1 - Effects of erythromycin on the propulsive motility of upper gastrointestinal tract in rats

AU - Karadi, O.

AU - Bodis, B.

AU - Mózsik, G.

PY - 1997

Y1 - 1997

N2 - The differences between the postprandial mixing or propulsion and the interdigestive motility of the gastrointestinal (GI) tract are already known. Earlier studies showed dose-dependent differences in the effects of erythromycin on interdigestive motility. The various GI side-effects (vomiting, diarrhoea) also suggest that there are different effects of erythromycin on the GI motility. The aim of our study was to examine postprandially the propulsive effects of different doses of erythromycin on the movement of intraluminal contents in the upper GI tract of the rat. The animals were fasted for 24 h before the experiments but water was given freely. The rats received 1.5 ml 1.5% methylcellulose painted with 0.05% phenol-red intragastrically (test solution). Erythromycin (E. lactobionate) was given intravenously at doses of 0.05, 0.1, 0.25, 0.5, 1.0 and 5.0 mg/kg 15 min before the administration of a test solution. The animals were sacrificed 20, 60 and 120 min after administration of methylcellulose, when the distance between the front of the painted intraluminal contents and the pylorus was measured and expressed as a percentage of the total length of small intestine. The phenol-red content in the stomach and small intestine was measured spectrophotometrically and the gastric emptying was calculated from the ratio of the measured total and intestinal phenol-red content. Our results showed that the small doses of erythromycin (0.1 and 0.25 mg/kg) accelerated gastric emptying after 20 min but did not change significantly the propulsive motility of upper small intestine; however, large doses of erythromycin (1.0 and 5.0 mg/kg) decreased gastric emptying and upper GI motility after 20 and 60 min. In summary, the prokinetic action of small doses of erythromycin was demonstrated, but its effect-time on GI motility is short and the ratio of the stimulating and inhibitory doses is 1:10.

AB - The differences between the postprandial mixing or propulsion and the interdigestive motility of the gastrointestinal (GI) tract are already known. Earlier studies showed dose-dependent differences in the effects of erythromycin on interdigestive motility. The various GI side-effects (vomiting, diarrhoea) also suggest that there are different effects of erythromycin on the GI motility. The aim of our study was to examine postprandially the propulsive effects of different doses of erythromycin on the movement of intraluminal contents in the upper GI tract of the rat. The animals were fasted for 24 h before the experiments but water was given freely. The rats received 1.5 ml 1.5% methylcellulose painted with 0.05% phenol-red intragastrically (test solution). Erythromycin (E. lactobionate) was given intravenously at doses of 0.05, 0.1, 0.25, 0.5, 1.0 and 5.0 mg/kg 15 min before the administration of a test solution. The animals were sacrificed 20, 60 and 120 min after administration of methylcellulose, when the distance between the front of the painted intraluminal contents and the pylorus was measured and expressed as a percentage of the total length of small intestine. The phenol-red content in the stomach and small intestine was measured spectrophotometrically and the gastric emptying was calculated from the ratio of the measured total and intestinal phenol-red content. Our results showed that the small doses of erythromycin (0.1 and 0.25 mg/kg) accelerated gastric emptying after 20 min but did not change significantly the propulsive motility of upper small intestine; however, large doses of erythromycin (1.0 and 5.0 mg/kg) decreased gastric emptying and upper GI motility after 20 and 60 min. In summary, the prokinetic action of small doses of erythromycin was demonstrated, but its effect-time on GI motility is short and the ratio of the stimulating and inhibitory doses is 1:10.

KW - erythromycin

KW - gastrointestinal tract

KW - postprandial propulsive motility

UR - http://www.scopus.com/inward/record.url?scp=0031044745&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031044745&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0031044745

VL - 5

SP - 77

EP - 82

JO - Inflammopharmacology

JF - Inflammopharmacology

SN - 0925-4692

IS - 1

ER -