Effects of energy restriction on thyroid hormone metabolism in chickens

Andrea Gyorffy, Ahmed Sayed-Ahmed, A. Zsarnovszky, L. Frenyó, Eddy Decuypere, T. Bartha

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Energy restriction induces changes in thyroid hormone economy in the form of a complex adaptation mechanism, in order to conserve energy storage and protein reserves. In the present work, thyroid hormone serum concentrations, hepatic deiodinase enzyme activities and hepatic deiodinase mRNA expression were examined after feed restriction and fasting. We demonstrate that during energy restriction, T 3 concentration is lowered due to a decreased T 4 activation and increased T 3 inactivation. We show that hepatic type-I deiodinase (D1) is not affected by energy restriction, however, hepatic D2 is decreased on both transcriptional and enzyme activity levels. Furthermore, hepatic D3 is increased after feed restriction in the liver. We also show that the hypothalamic feedback is not involved in the changes in serum T 3 and T 4 concentrations. Our data indicate that D2 enzyme contributes to the special hormone-exporting role of the chicken liver and this enzyme can be modulated by feed restriction.

Original languageEnglish
Pages (from-to)319-330
Number of pages12
JournalActa Veterinaria Hungarica
Volume57
Issue number2
DOIs
Publication statusPublished - Jun 1 2009

Fingerprint

hormone metabolism
thyroid hormones
Thyroid Hormones
Chickens
chickens
liver
Liver
energy
Iodide Peroxidase
restricted feeding
Enzymes
enzyme activity
enzymes
Serum
fasting
Fasting
inactivation
hormones
Hormones
Messenger RNA

Keywords

  • Chicken
  • Deiodination
  • Energy restriction
  • Liver

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effects of energy restriction on thyroid hormone metabolism in chickens. / Gyorffy, Andrea; Sayed-Ahmed, Ahmed; Zsarnovszky, A.; Frenyó, L.; Decuypere, Eddy; Bartha, T.

In: Acta Veterinaria Hungarica, Vol. 57, No. 2, 01.06.2009, p. 319-330.

Research output: Contribution to journalArticle

Gyorffy, Andrea ; Sayed-Ahmed, Ahmed ; Zsarnovszky, A. ; Frenyó, L. ; Decuypere, Eddy ; Bartha, T. / Effects of energy restriction on thyroid hormone metabolism in chickens. In: Acta Veterinaria Hungarica. 2009 ; Vol. 57, No. 2. pp. 319-330.
@article{639fe1dc0d7f49c098834d4e7d0bd2e7,
title = "Effects of energy restriction on thyroid hormone metabolism in chickens",
abstract = "Energy restriction induces changes in thyroid hormone economy in the form of a complex adaptation mechanism, in order to conserve energy storage and protein reserves. In the present work, thyroid hormone serum concentrations, hepatic deiodinase enzyme activities and hepatic deiodinase mRNA expression were examined after feed restriction and fasting. We demonstrate that during energy restriction, T 3 concentration is lowered due to a decreased T 4 activation and increased T 3 inactivation. We show that hepatic type-I deiodinase (D1) is not affected by energy restriction, however, hepatic D2 is decreased on both transcriptional and enzyme activity levels. Furthermore, hepatic D3 is increased after feed restriction in the liver. We also show that the hypothalamic feedback is not involved in the changes in serum T 3 and T 4 concentrations. Our data indicate that D2 enzyme contributes to the special hormone-exporting role of the chicken liver and this enzyme can be modulated by feed restriction.",
keywords = "Chicken, Deiodination, Energy restriction, Liver",
author = "Andrea Gyorffy and Ahmed Sayed-Ahmed and A. Zsarnovszky and L. Freny{\'o} and Eddy Decuypere and T. Bartha",
year = "2009",
month = "6",
day = "1",
doi = "10.1556/AVet.57.2009.2.12",
language = "English",
volume = "57",
pages = "319--330",
journal = "Acta Veterinaria Hungarica",
issn = "0236-6290",
publisher = "Akademiai Kiado",
number = "2",

}

TY - JOUR

T1 - Effects of energy restriction on thyroid hormone metabolism in chickens

AU - Gyorffy, Andrea

AU - Sayed-Ahmed, Ahmed

AU - Zsarnovszky, A.

AU - Frenyó, L.

AU - Decuypere, Eddy

AU - Bartha, T.

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Energy restriction induces changes in thyroid hormone economy in the form of a complex adaptation mechanism, in order to conserve energy storage and protein reserves. In the present work, thyroid hormone serum concentrations, hepatic deiodinase enzyme activities and hepatic deiodinase mRNA expression were examined after feed restriction and fasting. We demonstrate that during energy restriction, T 3 concentration is lowered due to a decreased T 4 activation and increased T 3 inactivation. We show that hepatic type-I deiodinase (D1) is not affected by energy restriction, however, hepatic D2 is decreased on both transcriptional and enzyme activity levels. Furthermore, hepatic D3 is increased after feed restriction in the liver. We also show that the hypothalamic feedback is not involved in the changes in serum T 3 and T 4 concentrations. Our data indicate that D2 enzyme contributes to the special hormone-exporting role of the chicken liver and this enzyme can be modulated by feed restriction.

AB - Energy restriction induces changes in thyroid hormone economy in the form of a complex adaptation mechanism, in order to conserve energy storage and protein reserves. In the present work, thyroid hormone serum concentrations, hepatic deiodinase enzyme activities and hepatic deiodinase mRNA expression were examined after feed restriction and fasting. We demonstrate that during energy restriction, T 3 concentration is lowered due to a decreased T 4 activation and increased T 3 inactivation. We show that hepatic type-I deiodinase (D1) is not affected by energy restriction, however, hepatic D2 is decreased on both transcriptional and enzyme activity levels. Furthermore, hepatic D3 is increased after feed restriction in the liver. We also show that the hypothalamic feedback is not involved in the changes in serum T 3 and T 4 concentrations. Our data indicate that D2 enzyme contributes to the special hormone-exporting role of the chicken liver and this enzyme can be modulated by feed restriction.

KW - Chicken

KW - Deiodination

KW - Energy restriction

KW - Liver

UR - http://www.scopus.com/inward/record.url?scp=68249149270&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68249149270&partnerID=8YFLogxK

U2 - 10.1556/AVet.57.2009.2.12

DO - 10.1556/AVet.57.2009.2.12

M3 - Article

VL - 57

SP - 319

EP - 330

JO - Acta Veterinaria Hungarica

JF - Acta Veterinaria Hungarica

SN - 0236-6290

IS - 2

ER -