Effects of energy expenditure gene polymorphisms on obesity-related traits in obese children

Katalin Csernus, Gábor Pauler, Éva Erhardt, Éva Lányi, Dénes Molnár

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4 Citations (Scopus)

Abstract

Objective To assess the frequencies of common polymorphisms of genes associated with energy expenditure among Hungarian obese children and investigate their influences on obesity-related traits and metabolic complications of common childhood obesity. Research methods and procedures In a total of 528 obese children (age 13.2 ± 2.6 years) an oral glucose tolerance test and determination of fasting serum lipid levels were carried out, blood pressure and resting energy expenditure were measured and the children were genotyped for the following gene polymorphisms: Trp64Arg of β3-adrenoreceptor (ADRB3), -3826 A/G of uncoupling protein (UCP)-1, exon 8 45 bp del/ins and -866 G/A of UCP-2, -55 C/T of UCP-3, and Pro12Ala of peroxisome-proliferator activated receptor gamma-2. Results Carriers of the ADRB3 Arg64 allele had a significantly higher relative body weight and relative body mass index compared with non-carriers. The UCP-2 exon 8 del/ins polymorphism was associated with higher degree of obesity, insulin resistance, dyslipideamia and lower adjusted metabolic rate. Children with UCP-3 -55 T/T genotype had a significantly lower adjusted metabolic rate than the C allele carriers. Conclusion We found evidence for associations between common polymorphisms of the ADRB3, the UCP-2 and UCP-3 genes and basic metabolic rate as well as level and metabolic consequences of common obesity among Hungarian school-aged children.

Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalObesity Research and Clinical Practice
Volume9
Issue number2
DOIs
Publication statusPublished - Mar 1 2015

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Keywords

  • Childhood obesity
  • Energy metabolism
  • Gene polymorphism
  • Metabolic complications

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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