Effects of electrical stimulation of the Gasserian ganglion on regional cerebral blood flow after induced subarachnoid hemorrhage in pigs evaluated by 99mTc-HMPAO-SPECT

H. Ebel, G. Semmelmann, M. Friese, M. Volz, J. Y. Lee, M. Dück, K. Schomäcker, J. Varga, I. Furka, R. Schröder, N. Klug

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

It could be demonstrated that cervical spinal cord stimulation increases cerebral blood flow. The effects of electrical stimulation of the trigeminal ganglion in the acute phase of SAH in pigs were investigated. The experiments were carried out on 11 domestic pigs divided in two groups (group I: SAH [n = 5]; group II: SAH and trigeminal stimulation [n = 6]). In all animals a native SPECT was performed. The Gasserian ganglion was exposed for inserting the stimulation electrode. SAH was induced by injecting 10 ml autologous blood through a catheter placed in the suprasellar cistern. 30 minutes after SAH-induction electrical stimulation was started for two hours in group II (2.8-4.5 V, 50 Hz, 300 μs). 99mTc-HMPAO (400-540 MBq) was injected intravenousely 110 minutes later. In group I 99mTc-HMPAO was applied after the same time interval. 80 minutes later SPECT was performed. Data were processed to calculate the uptake of radioactivity (%/kg tissue weight). The mean values were calculated for the different groups: native animal examination (%/kg tissue weight): 0.6343; group I: 0.468; group II: 0.6533. Comparing the mean values a highly significant difference between group I and group II (p <0.01) and between native examination and group I (p <0.01) could be found. No statistical significance could be detected on comparing the left/right-ratio in any ROI. The electrical stimulation of the Gasserian ganglion leads to a significantly increased uptake of 99mTc-HMPAO after induced SAH. Maybe the stimulation of the Gasserian ganglion constitutes a new therapeutic modality treating disturbed rCBF after SAH.

Original languageEnglish
Pages (from-to)50-57
Number of pages8
JournalMinimally Invasive Neurosurgery
Volume44
Issue number1
DOIs
Publication statusPublished - 2001

Fingerprint

Cerebrovascular Circulation
Technetium Tc 99m Exametazime
Trigeminal Ganglion
Regional Blood Flow
Subarachnoid Hemorrhage
Single-Photon Emission-Computed Tomography
Electric Stimulation
Swine
Spinal Cord Stimulation
Weights and Measures
Sus scrofa
Radioactivity
Electrodes
Catheters

Keywords

  • RCBF
  • SAH
  • SPECT
  • Trigeminal stimulation

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Effects of electrical stimulation of the Gasserian ganglion on regional cerebral blood flow after induced subarachnoid hemorrhage in pigs evaluated by 99mTc-HMPAO-SPECT. / Ebel, H.; Semmelmann, G.; Friese, M.; Volz, M.; Lee, J. Y.; Dück, M.; Schomäcker, K.; Varga, J.; Furka, I.; Schröder, R.; Klug, N.

In: Minimally Invasive Neurosurgery, Vol. 44, No. 1, 2001, p. 50-57.

Research output: Contribution to journalArticle

Ebel, H. ; Semmelmann, G. ; Friese, M. ; Volz, M. ; Lee, J. Y. ; Dück, M. ; Schomäcker, K. ; Varga, J. ; Furka, I. ; Schröder, R. ; Klug, N. / Effects of electrical stimulation of the Gasserian ganglion on regional cerebral blood flow after induced subarachnoid hemorrhage in pigs evaluated by 99mTc-HMPAO-SPECT. In: Minimally Invasive Neurosurgery. 2001 ; Vol. 44, No. 1. pp. 50-57.
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abstract = "It could be demonstrated that cervical spinal cord stimulation increases cerebral blood flow. The effects of electrical stimulation of the trigeminal ganglion in the acute phase of SAH in pigs were investigated. The experiments were carried out on 11 domestic pigs divided in two groups (group I: SAH [n = 5]; group II: SAH and trigeminal stimulation [n = 6]). In all animals a native SPECT was performed. The Gasserian ganglion was exposed for inserting the stimulation electrode. SAH was induced by injecting 10 ml autologous blood through a catheter placed in the suprasellar cistern. 30 minutes after SAH-induction electrical stimulation was started for two hours in group II (2.8-4.5 V, 50 Hz, 300 μs). 99mTc-HMPAO (400-540 MBq) was injected intravenousely 110 minutes later. In group I 99mTc-HMPAO was applied after the same time interval. 80 minutes later SPECT was performed. Data were processed to calculate the uptake of radioactivity ({\%}/kg tissue weight). The mean values were calculated for the different groups: native animal examination ({\%}/kg tissue weight): 0.6343; group I: 0.468; group II: 0.6533. Comparing the mean values a highly significant difference between group I and group II (p <0.01) and between native examination and group I (p <0.01) could be found. No statistical significance could be detected on comparing the left/right-ratio in any ROI. The electrical stimulation of the Gasserian ganglion leads to a significantly increased uptake of 99mTc-HMPAO after induced SAH. Maybe the stimulation of the Gasserian ganglion constitutes a new therapeutic modality treating disturbed rCBF after SAH.",
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AU - Semmelmann, G.

AU - Friese, M.

AU - Volz, M.

AU - Lee, J. Y.

AU - Dück, M.

AU - Schomäcker, K.

AU - Varga, J.

AU - Furka, I.

AU - Schröder, R.

AU - Klug, N.

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AB - It could be demonstrated that cervical spinal cord stimulation increases cerebral blood flow. The effects of electrical stimulation of the trigeminal ganglion in the acute phase of SAH in pigs were investigated. The experiments were carried out on 11 domestic pigs divided in two groups (group I: SAH [n = 5]; group II: SAH and trigeminal stimulation [n = 6]). In all animals a native SPECT was performed. The Gasserian ganglion was exposed for inserting the stimulation electrode. SAH was induced by injecting 10 ml autologous blood through a catheter placed in the suprasellar cistern. 30 minutes after SAH-induction electrical stimulation was started for two hours in group II (2.8-4.5 V, 50 Hz, 300 μs). 99mTc-HMPAO (400-540 MBq) was injected intravenousely 110 minutes later. In group I 99mTc-HMPAO was applied after the same time interval. 80 minutes later SPECT was performed. Data were processed to calculate the uptake of radioactivity (%/kg tissue weight). The mean values were calculated for the different groups: native animal examination (%/kg tissue weight): 0.6343; group I: 0.468; group II: 0.6533. Comparing the mean values a highly significant difference between group I and group II (p <0.01) and between native examination and group I (p <0.01) could be found. No statistical significance could be detected on comparing the left/right-ratio in any ROI. The electrical stimulation of the Gasserian ganglion leads to a significantly increased uptake of 99mTc-HMPAO after induced SAH. Maybe the stimulation of the Gasserian ganglion constitutes a new therapeutic modality treating disturbed rCBF after SAH.

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