Effects of early aging and cerebral hypoperfusion on spreading depression in rats

Eszter Farkas, Tihomir P. Obrenovitch, Ádám Institóris, Ferenc Bari

Research output: Contribution to journalArticle

20 Citations (Scopus)


Cortical spreading depression (CSD) is a feature of stroke pathophysiology. As stroke incidence increases with age, we have examined the effects of early aging and chronic cerebral hypoperfusion on CSD in rats.Three groups were studied: Young, 2-month-old animals; Middle-aged-2VO, subjected to 8 months of bilateral carotid occlusion from 2-month-of-age; and Middle-aged-SHAM, sham-operated. At 2- and 10-month-of-age for the Young and Middle-aged groups, recurrent CSD were induced under halothane anesthesia, by sustained application of 1. M KCl to the cortex for 2. h. Propagating CSD (i.e., cortical EEG, direct current potential) and associated laser Doppler blood flow changes were recorded anteriorly.Susceptibility to CSD and event duration were both decreased by early aging (frequency: 21 ± 0.5 and 6 ± 0.5 CSD/h; duration: 139 ± 7 and 63 ± 8. s; in Young and Middle-aged-SHAM, respectively). There was also a tendency for CSD-associated hyperemia to be reduced in the Middle-aged-2VO group (8.9 ± 2.1 vs. 32.8 ± 12.6% × min in Young). These data suggest reduced sensitivity of the cortex to CSD elicitation with early aging, and a less responsive cerebrovascular system with chronic hypoperfusion.

Original languageEnglish
Pages (from-to)1707-1715
Number of pages9
JournalNeurobiology of Aging
Issue number9
Publication statusPublished - Sep 1 2011


  • Aging
  • Cerebral blood flow
  • Chronic cerebral hypoperfusion
  • Cortical spreading depression
  • Electrophysiology
  • Laser Doppler flowmetry
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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