Effects of drugs on the production of stress ulcer in the rat.

L. Nagy, G. Mózsik, M. Figler, E. Gerber, T. Past, C. Ruzsa, Z. Vezekényi, T. Jávor

Research output: Contribution to journalArticle

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Abstract

The authors studied the effect of drugs with different mechanisms of action on the prevention of stress ulcer production in the rat. Stress ulcer was induced by a method developed by the authors: intact, starved rats were swum in water at 23 degrees C for 5 hours. Atropine (0.1-0.5 and 1.0 mg/kg i.m.), cimetidine (1.0-5.0 and 25 mg/kg i.p.), prostacyclin (PGI2) (5.0-25.0 and 100 micrograms/kg i.p.) and phentolamine (0.35-1.75-3.5 and 7.0 mg/kg i.m.) were shown to decrease the production of stress ulcers significantly, in a dose-dependent fashion. Propranolol (0.35-1.75-3.5 and 7.0 mg/kg i.m.) did not influence the production of stress ulcers. The finding that drugs with different actions could considerably reduce or prevent the production of stress ulcer appears to indicate the complexity of the neural, hormonal and biochemical processes involved in the pathogenesis. On the basis of the present results the authors suggest the use of a preventive therapeutic regimen in clinical practice with an appropriate combination of drugs.

Original languageEnglish
Pages (from-to)219-227
Number of pages9
JournalActa Physiologica Academiae Scientiarum Hungaricae
Volume60
Issue number4
Publication statusPublished - 1982

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Ulcer
Pharmaceutical Preparations
Epoprostenol
Biochemical Phenomena
Phentolamine
Cimetidine
Drug Combinations
Atropine
Propranolol
Water
Therapeutics

ASJC Scopus subject areas

  • Physiology

Cite this

Effects of drugs on the production of stress ulcer in the rat. / Nagy, L.; Mózsik, G.; Figler, M.; Gerber, E.; Past, T.; Ruzsa, C.; Vezekényi, Z.; Jávor, T.

In: Acta Physiologica Academiae Scientiarum Hungaricae, Vol. 60, No. 4, 1982, p. 219-227.

Research output: Contribution to journalArticle

Nagy, L, Mózsik, G, Figler, M, Gerber, E, Past, T, Ruzsa, C, Vezekényi, Z & Jávor, T 1982, 'Effects of drugs on the production of stress ulcer in the rat.', Acta Physiologica Academiae Scientiarum Hungaricae, vol. 60, no. 4, pp. 219-227.
Nagy, L. ; Mózsik, G. ; Figler, M. ; Gerber, E. ; Past, T. ; Ruzsa, C. ; Vezekényi, Z. ; Jávor, T. / Effects of drugs on the production of stress ulcer in the rat. In: Acta Physiologica Academiae Scientiarum Hungaricae. 1982 ; Vol. 60, No. 4. pp. 219-227.
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