Effects of dipyridamole in spontaneously hypertensive rabbits with diffuse chronic cerebral ischemia

Katalin Hegedüs, István Fekete, László Molnár

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4 Citations (Scopus)

Abstract

The effect of intravenous dipyridamole (0.7 mg/kg) on cerebral blood flow (CBF), mean arterial blood pressure (MABP), heart rate, respiration rate, cerebral electrical activity, arterial blood gases, pH, and glucose was investigated in 14 normotensive and 14 stroke-prone spontaneously hypertensive anesthetized rabbits. CBF was measured by hydrogen and heat clearance. In both groups, MABP decreased (normotensive: -24 mm Hg, hypertensive: -47 mm Hg; ANOVA: P < 0.0001) and CBF increased (normotensive: +59 ml/100 g/min, hypertensive: +72 ml/100 g/min; ANOVA: P < 0.0002). CBF returned to the initial level 21 min later in hypertensive than in normotensive rabbits. Changes in other parameters were insignificant. In additional experiments, 30 mg/kg theophylline entirely prevented the cerebral vasodilator and systemic hypotensive effects of dipyridamole in both normotensive and hypertensive rabbits. We conclude that, in stroke-prone spontaneously hypertensive rabbits, the longer-lasting and larger CBF increase in response to dipyridamole may be attributed to reversible functional changes in the cerebral vasculature resulting from hypertension.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalEuropean Journal of Pharmacology
Volume237
Issue number2-3
DOIs
Publication statusPublished - Jun 24 1993

Keywords

  • Cerebral blood flow
  • Chronic cerebral ischaemia
  • Dipyradamole
  • Hypertension (rabbit)

ASJC Scopus subject areas

  • Pharmacology

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