Effects of dipeptides containing the amino acid, proline on the chemotaxis of Tetrahymena pyriformis. Evolutionary conclusions on the formation of hormone receptors and hormones

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Our investigations demonstrate that proline-containing dipeptides can provoke a chemosensory response from the unicellular Tetrahymena pyriformis. The chemotactic effects of the dipeptides have a close relationship with the side chain and the lipophilicity of the amino-terminal amino acid. Comparison of 'mirror' variants of proline-containing dipeptides points to the fact that dipeptides with small side chain and non-polar character amino acids (Gly-Pro, Ala-Pro) are preferred on the amino-terminal end. In the case of amino acids with very variable side chains, small (Pro-Gly) and the large side chain and non-polar character amino acids (Pro-Leu, Pro-Phe) on the carboxyl-terminal end can induce significant chemotactic responses. With valine on any terminus the proline-containing dipeptide induced a weak repellent effect.

Original languageEnglish
Pages (from-to)341-345
Number of pages5
JournalCell biology international
Volume21
Issue number6
DOIs
Publication statusPublished - Jun 1997

    Fingerprint

Keywords

  • Dipeptide
  • Hormone evolution
  • Proline
  • Receptor evolution
  • Tetrahymena

ASJC Scopus subject areas

  • Cell Biology

Cite this