Effects of different types of isocaloric parenteral nutrients on food intake and metabolic concomitants

G. Bodoky, Michael M. Meguid, Zhong Jin Yang, Alessandro Laviano

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Whether spontaneous food intake (SFI) is controlled by infused nutrient type or its caloric content, irrespective of nutrient type, was investigated. Rats were infused for 4 days with isocaloric solutions of different nutrient type but sharing the same intermediary metabolic oxidative pathway, providing 25% of daily caloric needs. One parenteral solution was a glucose, fat and amino acid mix (TPN-25%); the other provided ketone bodies (TRO-3.5%). Effects of parenteral infusions on SFI and metabolic concomitants were compared and contrasted to that in a group of orally fed rats. Both infusions reduced SFI by 50%. Rats receiving TRI-3.5% had lower blood glucose and insulin concentrations, but increased hepatic glycogen content compared to TPN-25% or orally fed rats. No differences in hepatic triglycerides occurred between the three groups. However, serum free fatty acids were significantly lower in TRI-3.5% and in TPN-25% groups vs. fed rats. Data indicate food intake suppression is mediated by caloric content rather than nutrient type, suggesting that a mediator of SFI regulation could be at the citric acid cycle level.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalPhysiology and Behavior
Volume58
Issue number1
DOIs
Publication statusPublished - 1995

Fingerprint

Eating
Food
Parenteral Infusions
Appetite Regulation
Ketone Bodies
Liver Glycogen
Citric Acid Cycle
Metabolic Networks and Pathways
Nonesterified Fatty Acids
Blood Glucose
Triglycerides
Fats
Insulin
Amino Acids
Glucose
Liver
Serum

Keywords

  • Citric acid cycle
  • Control food intake
  • Free fatty acids
  • Glucose
  • Glycogen
  • Insulin
  • Intravenous nutrient infusions
  • Ketone bodies
  • Parenteral nutrients
  • Rat
  • Spontaneous food intake
  • Total caloric intake
  • Triglycerides

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology
  • Physiology (medical)

Cite this

Effects of different types of isocaloric parenteral nutrients on food intake and metabolic concomitants. / Bodoky, G.; Meguid, Michael M.; Yang, Zhong Jin; Laviano, Alessandro.

In: Physiology and Behavior, Vol. 58, No. 1, 1995, p. 75-79.

Research output: Contribution to journalArticle

Bodoky, G. ; Meguid, Michael M. ; Yang, Zhong Jin ; Laviano, Alessandro. / Effects of different types of isocaloric parenteral nutrients on food intake and metabolic concomitants. In: Physiology and Behavior. 1995 ; Vol. 58, No. 1. pp. 75-79.
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