Effects of different stressors are modulated by different neurobiological systems: The role of GABA-A versus CB1 receptor gene variants in anxiety and depression

X. Gonda, Peter Petschner, Nora Eszlari, Sara Sutori, Zsofia Gal, Szabolcs Koncz, Ian M. Anderson, Bill Deakin, G. Juhász, Gyorgy Bagdy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Environmental stress and its interaction with genetic variation are key contributors in the development of depression and anxiety, yet there is a failure to identify replicable genetic variants and gene-interaction effects in the background of these psychiatric symptoms. Recently it has been reported that 5-HTTLPR and NOSI interact with financial but not other types of recent stressors in the development of depression. In the present study we investigated the interaction of GABRA6 rs3219151 and CNR1 rs7766029 in interaction with different types of recent life events on the presence of depression and anxiety in a large general population sample. 2191 participants completed the List of Threatening Experiences questionnaire which covers four categories of stressful life events (financial problems, illness/personal problems, intimate relationships, and social network) experienced over the previous year and the Brief Symptom Inventory for depression and anxiety symptoms. Participants were genotyped for rs3219151 and rs7766029. Data were analyzed with linear regression models with age and gender as covariates. Results indicated that CNR1 rs7766029 interacted significantly with financial but not other types of life events both in case of depression and anxiety symptoms. In contrast, GABRA6 rs3219151 showed a significant interaction with social network related life events in case of anxiety and with illness/personal problem-related life events in case of depression. Our results suggest that the psychological impact of different types of recent stress may be differentially modulated by distinct molecular genetic pathways. Furthermore, in case of certain genetic variants, the occurring psychiatric symptom may depend on the type of stress experienced.

Original languageEnglish
Article number138
JournalFrontiers in Cellular Neuroscience
Volume13
DOIs
Publication statusPublished - Jan 29 2019

Fingerprint

Cannabinoid Receptor CB1
gamma-Aminobutyric Acid
Anxiety
Depression
Genes
Social Support
Psychiatry
Linear Models
Molecular Biology
Psychology
Equipment and Supplies
Population

Keywords

  • Anxiety
  • CNR1
  • Depression
  • Endocannabinoid system
  • GABA
  • GABRA6
  • Gene-environment interaction
  • Types of stress

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Effects of different stressors are modulated by different neurobiological systems : The role of GABA-A versus CB1 receptor gene variants in anxiety and depression. / Gonda, X.; Petschner, Peter; Eszlari, Nora; Sutori, Sara; Gal, Zsofia; Koncz, Szabolcs; Anderson, Ian M.; Deakin, Bill; Juhász, G.; Bagdy, Gyorgy.

In: Frontiers in Cellular Neuroscience, Vol. 13, 138, 29.01.2019.

Research output: Contribution to journalArticle

Gonda, X. ; Petschner, Peter ; Eszlari, Nora ; Sutori, Sara ; Gal, Zsofia ; Koncz, Szabolcs ; Anderson, Ian M. ; Deakin, Bill ; Juhász, G. ; Bagdy, Gyorgy. / Effects of different stressors are modulated by different neurobiological systems : The role of GABA-A versus CB1 receptor gene variants in anxiety and depression. In: Frontiers in Cellular Neuroscience. 2019 ; Vol. 13.
@article{4f96c1c14a474903ae58915afa41e0e5,
title = "Effects of different stressors are modulated by different neurobiological systems: The role of GABA-A versus CB1 receptor gene variants in anxiety and depression",
abstract = "Environmental stress and its interaction with genetic variation are key contributors in the development of depression and anxiety, yet there is a failure to identify replicable genetic variants and gene-interaction effects in the background of these psychiatric symptoms. Recently it has been reported that 5-HTTLPR and NOSI interact with financial but not other types of recent stressors in the development of depression. In the present study we investigated the interaction of GABRA6 rs3219151 and CNR1 rs7766029 in interaction with different types of recent life events on the presence of depression and anxiety in a large general population sample. 2191 participants completed the List of Threatening Experiences questionnaire which covers four categories of stressful life events (financial problems, illness/personal problems, intimate relationships, and social network) experienced over the previous year and the Brief Symptom Inventory for depression and anxiety symptoms. Participants were genotyped for rs3219151 and rs7766029. Data were analyzed with linear regression models with age and gender as covariates. Results indicated that CNR1 rs7766029 interacted significantly with financial but not other types of life events both in case of depression and anxiety symptoms. In contrast, GABRA6 rs3219151 showed a significant interaction with social network related life events in case of anxiety and with illness/personal problem-related life events in case of depression. Our results suggest that the psychological impact of different types of recent stress may be differentially modulated by distinct molecular genetic pathways. Furthermore, in case of certain genetic variants, the occurring psychiatric symptom may depend on the type of stress experienced.",
keywords = "Anxiety, CNR1, Depression, Endocannabinoid system, GABA, GABRA6, Gene-environment interaction, Types of stress",
author = "X. Gonda and Peter Petschner and Nora Eszlari and Sara Sutori and Zsofia Gal and Szabolcs Koncz and Anderson, {Ian M.} and Bill Deakin and G. Juh{\'a}sz and Gyorgy Bagdy",
year = "2019",
month = "1",
day = "29",
doi = "10.3389/fncel.2019.00138",
language = "English",
volume = "13",
journal = "Frontiers in Cellular Neuroscience",
issn = "1662-5102",
publisher = "Frontiers Research Foundation",

}

TY - JOUR

T1 - Effects of different stressors are modulated by different neurobiological systems

T2 - The role of GABA-A versus CB1 receptor gene variants in anxiety and depression

AU - Gonda, X.

AU - Petschner, Peter

AU - Eszlari, Nora

AU - Sutori, Sara

AU - Gal, Zsofia

AU - Koncz, Szabolcs

AU - Anderson, Ian M.

AU - Deakin, Bill

AU - Juhász, G.

AU - Bagdy, Gyorgy

PY - 2019/1/29

Y1 - 2019/1/29

N2 - Environmental stress and its interaction with genetic variation are key contributors in the development of depression and anxiety, yet there is a failure to identify replicable genetic variants and gene-interaction effects in the background of these psychiatric symptoms. Recently it has been reported that 5-HTTLPR and NOSI interact with financial but not other types of recent stressors in the development of depression. In the present study we investigated the interaction of GABRA6 rs3219151 and CNR1 rs7766029 in interaction with different types of recent life events on the presence of depression and anxiety in a large general population sample. 2191 participants completed the List of Threatening Experiences questionnaire which covers four categories of stressful life events (financial problems, illness/personal problems, intimate relationships, and social network) experienced over the previous year and the Brief Symptom Inventory for depression and anxiety symptoms. Participants were genotyped for rs3219151 and rs7766029. Data were analyzed with linear regression models with age and gender as covariates. Results indicated that CNR1 rs7766029 interacted significantly with financial but not other types of life events both in case of depression and anxiety symptoms. In contrast, GABRA6 rs3219151 showed a significant interaction with social network related life events in case of anxiety and with illness/personal problem-related life events in case of depression. Our results suggest that the psychological impact of different types of recent stress may be differentially modulated by distinct molecular genetic pathways. Furthermore, in case of certain genetic variants, the occurring psychiatric symptom may depend on the type of stress experienced.

AB - Environmental stress and its interaction with genetic variation are key contributors in the development of depression and anxiety, yet there is a failure to identify replicable genetic variants and gene-interaction effects in the background of these psychiatric symptoms. Recently it has been reported that 5-HTTLPR and NOSI interact with financial but not other types of recent stressors in the development of depression. In the present study we investigated the interaction of GABRA6 rs3219151 and CNR1 rs7766029 in interaction with different types of recent life events on the presence of depression and anxiety in a large general population sample. 2191 participants completed the List of Threatening Experiences questionnaire which covers four categories of stressful life events (financial problems, illness/personal problems, intimate relationships, and social network) experienced over the previous year and the Brief Symptom Inventory for depression and anxiety symptoms. Participants were genotyped for rs3219151 and rs7766029. Data were analyzed with linear regression models with age and gender as covariates. Results indicated that CNR1 rs7766029 interacted significantly with financial but not other types of life events both in case of depression and anxiety symptoms. In contrast, GABRA6 rs3219151 showed a significant interaction with social network related life events in case of anxiety and with illness/personal problem-related life events in case of depression. Our results suggest that the psychological impact of different types of recent stress may be differentially modulated by distinct molecular genetic pathways. Furthermore, in case of certain genetic variants, the occurring psychiatric symptom may depend on the type of stress experienced.

KW - Anxiety

KW - CNR1

KW - Depression

KW - Endocannabinoid system

KW - GABA

KW - GABRA6

KW - Gene-environment interaction

KW - Types of stress

UR - http://www.scopus.com/inward/record.url?scp=85064203413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064203413&partnerID=8YFLogxK

U2 - 10.3389/fncel.2019.00138

DO - 10.3389/fncel.2019.00138

M3 - Article

AN - SCOPUS:85064203413

VL - 13

JO - Frontiers in Cellular Neuroscience

JF - Frontiers in Cellular Neuroscience

SN - 1662-5102

M1 - 138

ER -