Effects of different cytokines on epidermal growth factor receptor expression by Jeg-3 choriocarcinoma cell line in vitro

V. Fulop, I. Szigetvari, J. Szepesi, M. A. Steller, S. R. Berkowitz

Research output: Contribution to journalArticle

Abstract

Lymphocytes and macrophages which infiltrate the host-tumor interface in choriocarcinoma, on activation by paternal antigens, produces soluble paracrine factors known as cytokines, which regulate cellular growth. The authors demonstrate that interleukin-1α, interleukin-1β and tumor necrosis factor - as human recombinant cytokines, significantly increase the epidermal growth factor receptor expression on JEG-3 choriocarcinoma cells and support the concept that cytokines are involved in choriocarcinoma cell growth through epidermal growth factor receptors.

Original languageEnglish
Pages (from-to)415-418
Number of pages4
JournalMagyar Noorvosok Lapja
Volume55
Issue number6
Publication statusPublished - Dec 1 1992

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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