Effects of desglycinamide-arginine-vasopressin (DG-AVP) on memory processes in diabetes insipidus patients and non-diabetic subjects

F. Laczi, J. M. van Ree, A. Wagner, Z. Valkusz, T. Járdánházy, G. L. Kovács, G. Telegdy, J. Szilárd, F. A. László, D. de Wied

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37 Citations (Scopus)

Abstract

The effects of desglycinamide9-arginine8-vasopressin (DG-AVP) on memory processes have been studied in patients with central diabetes insipidus (DI) and in non-diabetic control patients. Acute im injection of DG-AVP improved some aspects of short-term memory. Subchronic intranasal administration of DG-AVP facilitated short-term memory more consistently and in addition improved long-term memory. DG-AVP increased the attention, but only in the non-diabetic subjects. The effects of DG-AVP on memory processes persisted after discontinuation of treatment. DG-AVP did not affect the parameters for water and electrolyte metabolism, blood pressure and pulse rate neither in DI nor in the control patients. Thus, the memory effects of DG-AVP are probably mediated by a direct action on the central nervous system.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalUnknown Journal
Volume102
Issue number2
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Endocrinology

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