Effects of deita-9-tetrahydrocannabinol on thehypothalamic-pituitary control of luteinizing hormone and follicle-stimulating hormone secretion in adult male rats

T. Wenger, V. Rettori, G. D. Snyder, S. Dalterio, S. M. McCann

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The main psychoactive component of marihuana, delta-9-tetrahydrocannabinol (THC) was injected into the 3rd cerebral ventricle. A single dose of THC (2 μl of 10−6M) decreased serum LH temporarily but did not alter serum follicle-stimulating hormone (FSH) levels. The mediobasal hypothalamic (MBH) luteinizing hormone-releasing hormone(LHRH) content was elevated by 30 min after the injection. The elevation persisted for 1 h. Then, the LHRH contentreturned towards the preinjection level. In contrast, the LHRH in the organum vasculosum of the lamina terminalis did not change after a single dose of THC. The results indicate that THC alters pituitary LH release by inhibiting the release of LHRH which then increases in the MBH by continued synthesis or transport from rostral areas. In addition, the data support the existence of an FSH releasing factor, the release of which is not suppressed by this dose of THC. THC did notalter the release, storage or responsiveness to LHRH of cultured anterior pituitary cells, which further supports the view that its principal site of action is on the hypothalamus.

Original languageEnglish
Pages (from-to)488-493
Number of pages6
JournalNeuroendocrinology
Volume46
Issue number6
DOIs
Publication statusPublished - Jan 1 1987

Keywords

  • Anterior pituitary cell culture
  • Delta-9-Tetrahydrocannabinol
  • FSH
  • Hypothalamus
  • Intraventricular injection
  • LH
  • LHRH
  • Male rats
  • Marihuana
  • THC, FSH, LH release

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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