Effects of corticotropin-releasing hormone on ACTH, cortisol and 13,14-dihydro-15-keto prostaglandin E2 in patients with diabetes insipidus before and after captopril treatment

Sabina Zacharieva, Maria Andreeva, Maria Orbetzova, Marieluise Wippermann, I. Muchá, Katia Andonova, Stanka Sheitanova

Research output: Contribution to journalArticle

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Abstract

A corticotropin-releasing hormone (CRH) test was performed on 7 patients with central diabetes insipidus (DI) and on 7 healthy subjects. The test was repeated on the patients with DI after 3 days of oral treatment with captopril at a dose of 100 mg daily. No significant difference in the responses of plasma ACTH and cortisol to CRH between the patients and the controls was found. The short-term captopril treatment resulted in a significant decrease of both basal and CRH-stimufated ACTH and cortisol levels in the patients with DI. CRH did not induce any changes in the stable metabolite of prostaglandin E2 13,14-dihydro-15-keto-prostaglandin E2 (PGE2-M) in the patients with DI before or after the captopril treatment. The results obtained suggest that vasopressin is not an obligatory factor for a normal ACTH response to CRH. Angiotensin II (A II) is involved in the regulation of ACTH. This study confirmed our previous data showing the lack of any specific effect of CRH on PGE2 production.

Original languageEnglish
Pages (from-to)433-437
Number of pages5
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume54
Issue number6
DOIs
Publication statusPublished - Jun 1996

Fingerprint

Diabetes Insipidus
Corticotropin-Releasing Hormone
Captopril
Medical problems
Adrenocorticotropic Hormone
Hydrocortisone
Dinoprostone
Therapeutics
Neurogenic Diabetes Insipidus
Metabolites
Vasopressins
Angiotensin II
15-ketoprostaglandin E2
Healthy Volunteers
Plasmas

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Effects of corticotropin-releasing hormone on ACTH, cortisol and 13,14-dihydro-15-keto prostaglandin E2 in patients with diabetes insipidus before and after captopril treatment. / Zacharieva, Sabina; Andreeva, Maria; Orbetzova, Maria; Wippermann, Marieluise; Muchá, I.; Andonova, Katia; Sheitanova, Stanka.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 54, No. 6, 06.1996, p. 433-437.

Research output: Contribution to journalArticle

Zacharieva, Sabina ; Andreeva, Maria ; Orbetzova, Maria ; Wippermann, Marieluise ; Muchá, I. ; Andonova, Katia ; Sheitanova, Stanka. / Effects of corticotropin-releasing hormone on ACTH, cortisol and 13,14-dihydro-15-keto prostaglandin E2 in patients with diabetes insipidus before and after captopril treatment. In: Prostaglandins Leukotrienes and Essential Fatty Acids. 1996 ; Vol. 54, No. 6. pp. 433-437.
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