Effects of cocaine on the contents of neurohypophyseal hormones in the plasma and in different brain structures in rats

Z. Sarnyai, M. Vecsernyés, F. Laczi, É Bíró, G. Szabó, G. Kovács

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Abstract

The effects of acute and chronic cocaine treatments on the levels of the neurohypophyseal hormones oxytocin (OXT) and vasopressin (AVP) in the plasma and in different brain structures in rats were measured by radioimmunoassay (RIA). Acute cocaine treatment had no effect on the level of OXT in the plasma or in the amygdala, but increased OXT contents were measured in the hypothalamus and in the hippocampus. The OXT levels in the basal forebrain structures (including the septum and the nucleus accumbens) were decreased by a single dose of cocaine. The acute injection of cocaine increased the level of AVP in the plasma, and decreased contents of OXT were measured in the amygdala and in the basal forebrain. Repeated treatment with cocaine decreased the level of OXT in the plasma, hypothalamus and hippocampus. The AVP contents were decreased in all of the brain structures investigated, but no change was caused in the plasma level of AVP by repeated injections of cocaine. These results demonstrate complex, region-specific interactions between cocaine and the neurohypophyseal hormones in the brain and in the periphery underlying the alteration in behavioral and autonomic functions caused by acute and chronic cocaine exposure.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalNeuropeptides
Volume23
Issue number1
DOIs
Publication statusPublished - 1992

Fingerprint

Posterior Pituitary Hormones
Cocaine
Rats
Brain
Oxytocin
Plasmas
Vasopressins
Amygdala
Hypothalamus
Hippocampus
Injections
Nucleus Accumbens
Radioimmunoassay
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Effects of cocaine on the contents of neurohypophyseal hormones in the plasma and in different brain structures in rats. / Sarnyai, Z.; Vecsernyés, M.; Laczi, F.; Bíró, É; Szabó, G.; Kovács, G.

In: Neuropeptides, Vol. 23, No. 1, 1992, p. 27-31.

Research output: Contribution to journalArticle

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