Effects of clozapine, olanzapine, risperidone, and haloperidol on hostility among patients with schizophrenia

L. Citrome, J. Volavka, P. Czobor, B. Sheitman, J. P. Lindenmayer, J. McEvoy, T. B. Cooper, M. Chakos, J. A. Lieberman

Research output: Contribution to journalArticle

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Abstract

Objective: This study compared the specific antiaggressive effects of clozapine with those of olanzapine, risperidone, and haloperidol Methods: A total of 157 inpatients with schizophrenia or schizoaffective disorder and a history of suboptimal treatment response were randomly assigned to receive clozapine, olanzapine, risperidone, or haloperidol in a double-blind 14-week trial. The trial was divided into two periods: eight weeks during which the dosage was escalated and then fixed, and six weeks during which variable dosages were used. The hostility item of the Positive and Negative Syndrome Scale (PANSS) was the principal outcome measure. Covariates included the items that reflect positive symptoms of schizophrenia (delusions, suspiciousness or feelings of persecution, grandiosity, unusual thought content, conceptual disorganization, and hallucinations) and the sedation item of the Nurses Observation Scale for Inpatient Evaluation (NOSIE). Results: Patients differed in their treatment response as measured by the hostility item of the PANSS. The scores of patients taking clozapine indicated significantly greater improvement than those of patients taking haloperidol or risperidone. The effect on hostility appeared to be independent of the antipsychotic effect of clozapine on other PANSS items that reflect delusional thinking, a formal thought disorder, or hallucinations and independent of sedation as measured by the NOSIE. Neither risperidone nor olanzapine showed superiority to haloperidol. Conclusion: Clozapine has a relative advantage over other antipsychotics as a specific antihostility agent.

Original languageEnglish
Pages (from-to)1510-1514
Number of pages5
JournalPsychiatric Services
Volume52
Issue number11
DOIs
Publication statusPublished - 2001

Fingerprint

olanzapine
Hostility
Risperidone
Clozapine
Haloperidol
schizophrenia
Schizophrenia
nurse
Inpatients
Hallucinations
delusion
Antipsychotic Agents
evaluation
Nurses
Observation
Delusions
Psychotic Disorders
Emotions
Outcome Assessment (Health Care)
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Public Health, Environmental and Occupational Health
  • Health(social science)
  • Health Professions(all)

Cite this

Citrome, L., Volavka, J., Czobor, P., Sheitman, B., Lindenmayer, J. P., McEvoy, J., ... Lieberman, J. A. (2001). Effects of clozapine, olanzapine, risperidone, and haloperidol on hostility among patients with schizophrenia. Psychiatric Services, 52(11), 1510-1514. https://doi.org/10.1176/appi.ps.52.11.1510

Effects of clozapine, olanzapine, risperidone, and haloperidol on hostility among patients with schizophrenia. / Citrome, L.; Volavka, J.; Czobor, P.; Sheitman, B.; Lindenmayer, J. P.; McEvoy, J.; Cooper, T. B.; Chakos, M.; Lieberman, J. A.

In: Psychiatric Services, Vol. 52, No. 11, 2001, p. 1510-1514.

Research output: Contribution to journalArticle

Citrome, L, Volavka, J, Czobor, P, Sheitman, B, Lindenmayer, JP, McEvoy, J, Cooper, TB, Chakos, M & Lieberman, JA 2001, 'Effects of clozapine, olanzapine, risperidone, and haloperidol on hostility among patients with schizophrenia', Psychiatric Services, vol. 52, no. 11, pp. 1510-1514. https://doi.org/10.1176/appi.ps.52.11.1510
Citrome, L. ; Volavka, J. ; Czobor, P. ; Sheitman, B. ; Lindenmayer, J. P. ; McEvoy, J. ; Cooper, T. B. ; Chakos, M. ; Lieberman, J. A. / Effects of clozapine, olanzapine, risperidone, and haloperidol on hostility among patients with schizophrenia. In: Psychiatric Services. 2001 ; Vol. 52, No. 11. pp. 1510-1514.
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