Effects of clonidine and guanfacine in essential hypertension

C. Farsang, Károly Varga, Lidia Vajda, Sándor Alfldi, Judit Kapocsi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Daily doses of 0.3 mg clonidine and 3 mg guanfacine were equiactive in decreasing blood pressure and heart rate in 17 subjects with essential hypertension. Clonidine decreased cardiac output and guanfacine decreased total peripheral resistance, while clonidine had no effect on stroke volume but guanfacine increased it. Both clonidine and guanfacine decreased plasma renin activity. Naloxone, 0.4 mg iv, reversed the antihypertensive effect of clonidine but was ineffective even at higher doses (1.6 mg iv) when subjects were treated with placebo or guanfacine. It is suggested that the hemodynamic differences between the two centrally acting α2-adrenoceptor agonist antihypertensive drugs may at least in part result from the involvement of opioid mechanisms only in the action of clonidine.

Original languageEnglish
Pages (from-to)588-594
Number of pages7
JournalClinical Pharmacology and Therapeutics
Volume36
Issue number5
Publication statusPublished - Nov 1984

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Guanfacine
Clonidine
Antihypertensive Agents
Naloxone
Renin
Cardiac Output
Vascular Resistance
Stroke Volume
Adrenergic Receptors
Opioid Analgesics
Essential Hypertension
Heart Rate
Hemodynamics
Placebos
Blood Pressure

ASJC Scopus subject areas

  • Pharmacology

Cite this

Farsang, C., Varga, K., Vajda, L., Alfldi, S., & Kapocsi, J. (1984). Effects of clonidine and guanfacine in essential hypertension. Clinical Pharmacology and Therapeutics, 36(5), 588-594.

Effects of clonidine and guanfacine in essential hypertension. / Farsang, C.; Varga, Károly; Vajda, Lidia; Alfldi, Sándor; Kapocsi, Judit.

In: Clinical Pharmacology and Therapeutics, Vol. 36, No. 5, 11.1984, p. 588-594.

Research output: Contribution to journalArticle

Farsang, C, Varga, K, Vajda, L, Alfldi, S & Kapocsi, J 1984, 'Effects of clonidine and guanfacine in essential hypertension', Clinical Pharmacology and Therapeutics, vol. 36, no. 5, pp. 588-594.
Farsang, C. ; Varga, Károly ; Vajda, Lidia ; Alfldi, Sándor ; Kapocsi, Judit. / Effects of clonidine and guanfacine in essential hypertension. In: Clinical Pharmacology and Therapeutics. 1984 ; Vol. 36, No. 5. pp. 588-594.
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