Effects of cholecystokinin-related peptides on self-stimulation behaviour in rats

Mária Balázs, Helmut Schwarzberg, Botond Penke, Gyula Telegdy

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Abstract

The effects of cholecystokinin octapeptide sulfate ester (CCK-8-SE), its N-terminal tripeptide (CCK-2-4-SE) and its C-terminal tetrapeptide (CCK-5-8) were investigated on hypothalamic self-stimulation in rats. CCK-8-SE and CCK-5-8 in 400 pmole doses inhibited self-stimulation behaviour, while CCK-2-4-SE was ineffective. In 80 pmole doses the peptides showed no effect. It is suggested that CCK-5-8 itself influences self-stimulation behaviour.

Original languageEnglish
Pages (from-to)143-145
Number of pages3
JournalNeuropeptides
Volume11
Issue number3
DOIs
Publication statusPublished - Apr 1988

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ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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