Effects of Chelidonium majus extracts and major alkaloids on hERG potassium channels and on dog cardiac action potential - A safety approach

Péter Orvos, László Virág, László Tálosi, Zsuzsanna Hajdú, Dezso Csupor, Nikoletta Jedlinszki, Tamás Szél, András Varró, Judit Hohmann

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Chelidonium majus or greater celandine is spread throughout the world, and it is a very common and frequent component of modern phytotherapy. Although C. majus contains alkaloids with remarkable physiological effect, moreover, safety pharmacology properties of this plant are not widely clarified, medications prepared from this plant are often used internally. In our study the inhibitory effects of C. majus herb extracts and alkaloids on hERG potassium current as well as on cardiac action potential were investigated. Our data show that hydroalcoholic extracts of greater celandine and its alkaloids, especially berberine, chelidonine and sanguinarine have a significant hERG potassium channel blocking effect. These extracts and alkaloids also prolong the cardiac action potential in dog ventricular muscle. Therefore these compounds may consequently delay cardiac repolarization, which may result in the prolongation of the QT interval and increase the risk of potentially fatal ventricular arrhythmias.

Original languageEnglish
Pages (from-to)156-165
Number of pages10
JournalFitoterapia
Volume100
DOIs
Publication statusPublished - Jan 2015

Keywords

  • Arrhythmia
  • Cardiac action potential
  • Chelidonium majus
  • Greater celandine
  • QT interval
  • hERG

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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