Effects of CGRP on active avoidance behavior in rats

A. Kovács, G. Telegdy

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The effect of calcitonin gene-related peptide (CGRP) on the extinction of active avoidance behaviour was examined in rats. Three doses (250 ng, 500 ng and 1 μg) of the peptide were administered into the lateral brain ventricle (i.c.v.). CGRP delayed the extinction of an active avoidance response in a dose-dependent manner. To reveal any role of the transmitter systems in the action of exogenously administered CGRP, the animals were pretreated with different receptor blockers. CGRP induced a delay in the extinction of an active avoidance response, which could be prevented by haloperidol, propranolol, methysergide and naloxone. Phenoxybenamine, atropine and bicuculline were ineffective. The data suggest that dopaminergic, βadrenergic, serotonergic and opiate transmission are involved in the CGRP-induced behavioral alterations.

Original languageEnglish
Pages (from-to)429-435
Number of pages7
JournalPhysiology and Behavior
Volume58
Issue number3
DOIs
Publication statusPublished - Sep 1995

Keywords

  • Active avoidance behavior
  • CGRP
  • ICV administration
  • Rat
  • Receptor blockers
  • Transmitter systems

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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