A kardiovaszkuláris rizikófaktorok hatása az agyérbetegek hemoreológiai viszonyaira.

Translated title of the contribution: Effects of cardiovascular risk factors on hemorheologic parameters in cerebrovascular patients

L. Szapáry, Mónika Szóts, B. Horváth, Zsolt Márton, Tamás Alexy, Gábor Késmárky, I. Juricskay, Ferenc Nagy, Valéria Gaál, Anita Pálfi, Katalin Koltai, K. Tóth

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

INTRODUCTION: Hemorheological factors are of significance in the determination of flow characteristics of blood and play an important role in the pathogenesis of cerebrovascular diseases. AIMS AND METHODS: In this study the changes of rheological factors--hematocrit (Hct), plasma fibrinogen concentration (PFC), whole blood (WBV) and plasma viscosity (PV), red blood cell aggregation (AI) and deformability and the association between these parameters and cardiovascular risk factors were investigated in 297 patients (173 males, 124 females, mean age: 60 11 years) with chronic phase (3 months after onset) ischemic cerebrovascular diseases, and in 68 healthy volunteers (30 males, 38 females, mean age: 36 6 years). RESULTS: All investigated hemorheological factors were significantly (p <0.05-0.0001) elevated in cerebrovascular patients compared to normal controls, the rise in Hct, WBV and PV are some of the most prominent findings. In the group of hypertensive, hyperlipidemic patients, smokers and alcoholics Hct, PFC, WBV, PV and AI were significantly (p <0.05-0.0001) higher compared to healthy controls, the same factors except plasma fibrinogen concentration showed association with diabetic history. Comparing cerebrovascular patients with or without risk factors, the most severe hemorheological deficit was observed in patients with hyperlipidemia and smoking habits. CONCLUSIONS: In this study the authors proved in chronic ischemic cerebrovascular patients that hemorheological abnormalities persist in most cases for a long time after an acute stroke, significant correlation could be seen between blood rheology and cardiovascular risk factors. Examination of rheological parameters can support to choose the optimal medical treatment in the secondary prevention of stroke, correction of hemorheological disturbances can reduce the risk of recurrent stroke.

Original languageHungarian
Pages (from-to)1085-1090
Number of pages6
JournalOrvosi Hetilap
Volume144
Issue number22
Publication statusPublished - Jun 1 2003

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Hematocrit
Viscosity
Fibrinogen
Cerebrovascular Disorders
Stroke
Cell Aggregation
Rheology
Alcoholics
Secondary Prevention
Hyperlipidemias
Habits
Healthy Volunteers
Erythrocytes
Smoking
History
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A kardiovaszkuláris rizikófaktorok hatása az agyérbetegek hemoreológiai viszonyaira. / Szapáry, L.; Szóts, Mónika; Horváth, B.; Márton, Zsolt; Alexy, Tamás; Késmárky, Gábor; Juricskay, I.; Nagy, Ferenc; Gaál, Valéria; Pálfi, Anita; Koltai, Katalin; Tóth, K.

In: Orvosi Hetilap, Vol. 144, No. 22, 01.06.2003, p. 1085-1090.

Research output: Contribution to journalArticle

Szapáry, L, Szóts, M, Horváth, B, Márton, Z, Alexy, T, Késmárky, G, Juricskay, I, Nagy, F, Gaál, V, Pálfi, A, Koltai, K & Tóth, K 2003, 'A kardiovaszkuláris rizikófaktorok hatása az agyérbetegek hemoreológiai viszonyaira.', Orvosi Hetilap, vol. 144, no. 22, pp. 1085-1090.
Szapáry L, Szóts M, Horváth B, Márton Z, Alexy T, Késmárky G et al. A kardiovaszkuláris rizikófaktorok hatása az agyérbetegek hemoreológiai viszonyaira. Orvosi Hetilap. 2003 Jun 1;144(22):1085-1090.
Szapáry, L. ; Szóts, Mónika ; Horváth, B. ; Márton, Zsolt ; Alexy, Tamás ; Késmárky, Gábor ; Juricskay, I. ; Nagy, Ferenc ; Gaál, Valéria ; Pálfi, Anita ; Koltai, Katalin ; Tóth, K. / A kardiovaszkuláris rizikófaktorok hatása az agyérbetegek hemoreológiai viszonyaira. In: Orvosi Hetilap. 2003 ; Vol. 144, No. 22. pp. 1085-1090.
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abstract = "INTRODUCTION: Hemorheological factors are of significance in the determination of flow characteristics of blood and play an important role in the pathogenesis of cerebrovascular diseases. AIMS AND METHODS: In this study the changes of rheological factors--hematocrit (Hct), plasma fibrinogen concentration (PFC), whole blood (WBV) and plasma viscosity (PV), red blood cell aggregation (AI) and deformability and the association between these parameters and cardiovascular risk factors were investigated in 297 patients (173 males, 124 females, mean age: 60 11 years) with chronic phase (3 months after onset) ischemic cerebrovascular diseases, and in 68 healthy volunteers (30 males, 38 females, mean age: 36 6 years). RESULTS: All investigated hemorheological factors were significantly (p <0.05-0.0001) elevated in cerebrovascular patients compared to normal controls, the rise in Hct, WBV and PV are some of the most prominent findings. In the group of hypertensive, hyperlipidemic patients, smokers and alcoholics Hct, PFC, WBV, PV and AI were significantly (p <0.05-0.0001) higher compared to healthy controls, the same factors except plasma fibrinogen concentration showed association with diabetic history. Comparing cerebrovascular patients with or without risk factors, the most severe hemorheological deficit was observed in patients with hyperlipidemia and smoking habits. CONCLUSIONS: In this study the authors proved in chronic ischemic cerebrovascular patients that hemorheological abnormalities persist in most cases for a long time after an acute stroke, significant correlation could be seen between blood rheology and cardiovascular risk factors. Examination of rheological parameters can support to choose the optimal medical treatment in the secondary prevention of stroke, correction of hemorheological disturbances can reduce the risk of recurrent stroke.",
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AU - Szóts, Mónika

AU - Horváth, B.

AU - Márton, Zsolt

AU - Alexy, Tamás

AU - Késmárky, Gábor

AU - Juricskay, I.

AU - Nagy, Ferenc

AU - Gaál, Valéria

AU - Pálfi, Anita

AU - Koltai, Katalin

AU - Tóth, K.

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N2 - INTRODUCTION: Hemorheological factors are of significance in the determination of flow characteristics of blood and play an important role in the pathogenesis of cerebrovascular diseases. AIMS AND METHODS: In this study the changes of rheological factors--hematocrit (Hct), plasma fibrinogen concentration (PFC), whole blood (WBV) and plasma viscosity (PV), red blood cell aggregation (AI) and deformability and the association between these parameters and cardiovascular risk factors were investigated in 297 patients (173 males, 124 females, mean age: 60 11 years) with chronic phase (3 months after onset) ischemic cerebrovascular diseases, and in 68 healthy volunteers (30 males, 38 females, mean age: 36 6 years). RESULTS: All investigated hemorheological factors were significantly (p <0.05-0.0001) elevated in cerebrovascular patients compared to normal controls, the rise in Hct, WBV and PV are some of the most prominent findings. In the group of hypertensive, hyperlipidemic patients, smokers and alcoholics Hct, PFC, WBV, PV and AI were significantly (p <0.05-0.0001) higher compared to healthy controls, the same factors except plasma fibrinogen concentration showed association with diabetic history. Comparing cerebrovascular patients with or without risk factors, the most severe hemorheological deficit was observed in patients with hyperlipidemia and smoking habits. CONCLUSIONS: In this study the authors proved in chronic ischemic cerebrovascular patients that hemorheological abnormalities persist in most cases for a long time after an acute stroke, significant correlation could be seen between blood rheology and cardiovascular risk factors. Examination of rheological parameters can support to choose the optimal medical treatment in the secondary prevention of stroke, correction of hemorheological disturbances can reduce the risk of recurrent stroke.

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