Effects of cardiac resynchronization therapy on left ventricular mass and wall thickness in mild heart failure patients in MADIT-CRT

Valentina Kutyifa, Scott D. Solomon, Mikhail Bourgoun, Amil M. Shah, Anne Catherine Pouleur, Dorit Knappe, Scott McNitt, Paul J. Wang, B. Merkely, Marc Pfeffer, Arthur J. Moss, Wojciech Zareba

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: The effect of cardiac resynchronization therapy (CRT) on left ventricular wall thickness and left ventricular mass (LVM) is unknown. Objectives: To evaluate the effects of CRT on septal and posterior wall thickness (SWT and PWT) and LVM in patients with left bundle branch block (LBBB) and non-LBBB vs implantable cardioverter-defibrillator patients and to assess the relationship between CRT-induced changes and cardiac events. Methods: We investigated 843 patients with LBBB and 366 patients with non-LBBB enrolled in the Multicenter Automatic Defibrillator Implantation Trial - Cardiac Resynchronization Therapy (MADIT-CRT) trial to analyze changes in SWT, PWT, and LVM at 12 months and subsequent outcome. The primary end point was heart failure or death; secondary end points included ventricular tachycardia, ventricular fibrillation, or death. Results: In LBBB patients, reduction in SWT, PWT, and LVM was more pronounced in CRT defibrillator (CRT-D) than in implantable cardioverter-defibrillator (SWT:-6.7%±4.4% vs-1.0%±1.9%; PWT:-6.4%±4.3% vs-0.8%±1.9%; LVM:-23.6%±9.9% vs-5.1%±5.1%; P

Original languageEnglish
Pages (from-to)354-360
Number of pages7
JournalHeart Rhythm
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 2013

Fingerprint

Cardiac Resynchronization Therapy
Defibrillators
Bundle-Branch Block
Heart Failure
Implantable Defibrillators
Ventricular Fibrillation
Ventricular Tachycardia

Keywords

  • Cardiac resynchronization therapy
  • Heart failure
  • Implantable cardioverter-defibrillator
  • Left ventricular mass
  • Ventricular arrhythmia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Kutyifa, V., Solomon, S. D., Bourgoun, M., Shah, A. M., Pouleur, A. C., Knappe, D., ... Zareba, W. (2013). Effects of cardiac resynchronization therapy on left ventricular mass and wall thickness in mild heart failure patients in MADIT-CRT. Heart Rhythm, 10(3), 354-360. https://doi.org/10.1016/j.hrthm.2012.11.007

Effects of cardiac resynchronization therapy on left ventricular mass and wall thickness in mild heart failure patients in MADIT-CRT. / Kutyifa, Valentina; Solomon, Scott D.; Bourgoun, Mikhail; Shah, Amil M.; Pouleur, Anne Catherine; Knappe, Dorit; McNitt, Scott; Wang, Paul J.; Merkely, B.; Pfeffer, Marc; Moss, Arthur J.; Zareba, Wojciech.

In: Heart Rhythm, Vol. 10, No. 3, 03.2013, p. 354-360.

Research output: Contribution to journalArticle

Kutyifa, V, Solomon, SD, Bourgoun, M, Shah, AM, Pouleur, AC, Knappe, D, McNitt, S, Wang, PJ, Merkely, B, Pfeffer, M, Moss, AJ & Zareba, W 2013, 'Effects of cardiac resynchronization therapy on left ventricular mass and wall thickness in mild heart failure patients in MADIT-CRT', Heart Rhythm, vol. 10, no. 3, pp. 354-360. https://doi.org/10.1016/j.hrthm.2012.11.007
Kutyifa, Valentina ; Solomon, Scott D. ; Bourgoun, Mikhail ; Shah, Amil M. ; Pouleur, Anne Catherine ; Knappe, Dorit ; McNitt, Scott ; Wang, Paul J. ; Merkely, B. ; Pfeffer, Marc ; Moss, Arthur J. ; Zareba, Wojciech. / Effects of cardiac resynchronization therapy on left ventricular mass and wall thickness in mild heart failure patients in MADIT-CRT. In: Heart Rhythm. 2013 ; Vol. 10, No. 3. pp. 354-360.
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AU - Pouleur, Anne Catherine

AU - Knappe, Dorit

AU - McNitt, Scott

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