Effects of cannabinoids on hypothalamic and reproductive function

M. Maccarrone, T. Wenger

Research output: Chapter in Book/Report/Conference proceedingChapter

36 Citations (Scopus)

Abstract

Marijuana and cannabinoids have been shown to exert profound effects on hypothalamic regulatory functions and reproduction in both experimental animals and humans. Here we review the role of (endo) cannabinoids in the regulation of appetite and food intake. There is converging evidence that the hypothalamic endocannabinoid system changes after leptin treatment. Cannabinoid administration decreases heat production by altering hypothalamic neurotransmitter production. Experimental and human data have also shown that the endocannabinoid system is involved in the regulation of reproductive function at both central and peripheral levels. We discuss also the role of fatty acid amide hydrolase (FAAH) in gestation, and in particular the regulation of the activity of FAAH by progesterone and leptin. We show that endocannabinoids inhibit the release of leukaemia inhibitory factor (LIF) from peripheral T lymphocytes. Taken together, endocannabinoids not only help to maintain neuroendocrine homeostasis, but also take part in immunological changes occurring during early pregnancy.

Original languageEnglish
Title of host publicationHandbook of Experimental Pharmacology
Pages555-571
Number of pages17
Volume168
DOIs
Publication statusPublished - 2005

Publication series

NameHandbook of Experimental Pharmacology
Volume168
ISSN (Print)01712004
ISSN (Electronic)18650325

Fingerprint

Endocannabinoids
Cannabinoids
Leptin
Appetite Regulation
Leukemia Inhibitory Factor
Pregnancy
T-cells
Thermogenesis
Cannabis
Reproduction
Progesterone
Neurotransmitter Agents
Animals
Homeostasis
T-Lymphocytes
fatty-acid amide hydrolase
Therapeutics

Keywords

  • Appetite
  • Cytokines
  • Endocannabinoids
  • Hypothalamus
  • Lymphocytes
  • Pituitary
  • Pregnancy
  • Reproduction
  • Sex hormones
  • Thermoregulation

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry

Cite this

Maccarrone, M., & Wenger, T. (2005). Effects of cannabinoids on hypothalamic and reproductive function. In Handbook of Experimental Pharmacology (Vol. 168, pp. 555-571). (Handbook of Experimental Pharmacology; Vol. 168). https://doi.org/10.1007/3-540-26573-2-18

Effects of cannabinoids on hypothalamic and reproductive function. / Maccarrone, M.; Wenger, T.

Handbook of Experimental Pharmacology. Vol. 168 2005. p. 555-571 (Handbook of Experimental Pharmacology; Vol. 168).

Research output: Chapter in Book/Report/Conference proceedingChapter

Maccarrone, M & Wenger, T 2005, Effects of cannabinoids on hypothalamic and reproductive function. in Handbook of Experimental Pharmacology. vol. 168, Handbook of Experimental Pharmacology, vol. 168, pp. 555-571. https://doi.org/10.1007/3-540-26573-2-18
Maccarrone M, Wenger T. Effects of cannabinoids on hypothalamic and reproductive function. In Handbook of Experimental Pharmacology. Vol. 168. 2005. p. 555-571. (Handbook of Experimental Pharmacology). https://doi.org/10.1007/3-540-26573-2-18
Maccarrone, M. ; Wenger, T. / Effects of cannabinoids on hypothalamic and reproductive function. Handbook of Experimental Pharmacology. Vol. 168 2005. pp. 555-571 (Handbook of Experimental Pharmacology).
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