Effects of brain natriuretic peptide-32 on the extinction of active avoidance behavior in rats. Transmitter-mediated action

Amelia Bidzseranova, Jony Gueron, János Varga, Gyula Telegdy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Three doses of porcine brain natriuretic peptide (pBNP-32) were tested in regards to the extinction of active avoidance behavior following injection into the lateral brain ventricle in rats. This peptide delayed the extinction of the active avoidance reflex in a dose-dependent manner. To clarify the involvement of transitters in the action of the peptide, the animals were pretreated with different receptor blockers in doses that did not affect the behavior of the animals in this learning paradigm. Dopaminergic, cholinergic, and α- and β-adrenergic blockers effectively blocked the delaying action of pBNP-32, whereas GABAergic, serotoninergic, and opiateergic blockers were ineffective. The data suggest that the delaying action of pBNP-32 on the extinction of active avoidance behavior is mediated via dopaminergic and α- and β-adrenergic neuromediations.

Original languageEnglish
Pages (from-to)227-229
Number of pages3
JournalPhysiology and Behavior
Volume52
Issue number2
DOIs
Publication statusPublished - Aug 1992

Keywords

  • Behavior
  • Brain
  • Natriuretic
  • Neurotransmitters
  • Peptide-32

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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