Effects of atrial natriuretic peptide on the unicellular Tetrahymena pyriformis model.

Research output: Contribution to journalArticle

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Abstract

The vertebral hormone, atrial natriuretic peptide (ANP) has characteristic effects in Tetrahymena cells. ANP is able to induce the release of sodium ions, probably via the membrane rather than the contractile vacuole. The hormone is a potent inhibitor of Chinese ink-phagocytosis. A 10(-12) M concentration of ANP has the maximum positive effect on the division of cells but long-term treatments indicate the presence of a down-regulation-like mechanism. ANP has a strong chemoattractant characteristic between 10(-13) and 10(-11) M concentrations. Significant concentration dependent FITC-ANP binding at pretreatments of 10(-12) M suggest the presence of special receptor-dependent mechanisms which are responsible for the development of hormonal imprinting. The similarities between the most effective concentrations (10(-13) - 10(-12) M) and the human serum level of ANP shows that the effects of ANP have a more evolutionary background than previously considered.

Original languageEnglish
Pages (from-to)27-40
Number of pages14
JournalMicrobios
Volume82
Issue number330
Publication statusPublished - 1995

Fingerprint

Tetrahymena pyriformis
Atrial Natriuretic Factor
Hormones
Tetrahymena
Fluorescein-5-isothiocyanate
Chemotactic Factors
Vacuoles
Phagocytosis
Cell Division
Down-Regulation
Sodium
Ions
Membranes
Serum

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Effects of atrial natriuretic peptide on the unicellular Tetrahymena pyriformis model. / Kőhidai, L.; Csaba, G.; Karsa, J.

In: Microbios, Vol. 82, No. 330, 1995, p. 27-40.

Research output: Contribution to journalArticle

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