Effects of antioxidant therapy in experimentally induced heart infarcts

B. Török, E. Röth, V. Bär, Zs Pollák

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Experiments were performed on dog hearts following coronary ligation and treatment with synthetic antioxidant of dihydroquinoline type. Experimental groups were: (i) control dogs, (ii) dogs with ligation of descendens anterior coronary branch, (iii) coronary ligated dogs with antioxidant pretreatment and (iv) dogs with coronary ligation and simultaneous antioxidant infusion therapy. The heart infarction per se is accompanied by the disintegration of membrane polyunsaturated fatty acids expressed by increase of malondialdehyde (MDA) concentration and the impairment of natural scavenging characterized by the decrease of superoxide dismutase (SOD) and reduced glutathione (GSH) content. The oral pretreatment with antioxidant for 8 days prevented or decreased the unfavourable pathobiochemical responses. The acute infusion therapy exerted no immediate protection, nonetheless, it could decrease the severity of pathological signs.

Original languageEnglish
Pages (from-to)167-179
Number of pages13
JournalBasic Research in Cardiology
Volume81
Issue number2
DOIs
Publication statusPublished - Mar 1 1986

Keywords

  • free oxygen radicals
  • lipid peroxidation
  • myocardial infarct
  • scavenger action
  • synthetic antioxidant

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Effects of antioxidant therapy in experimentally induced heart infarcts'. Together they form a unique fingerprint.

  • Cite this